619.614:636.5:621. DOI 10.33861/2071-8020-2023-6-21-23 Makhieva B. M., Ozdemirova D. M., Dagaeva A. B., Kabardiev S. Sh., Lysenko A. A. Summary. The intensive development of industrial poultry farming poses an urgent task for veterinary science to develop new and improve existing methods of combating various invasive and infectious diseases of birds. The successful development of this task will contribute to further specialization and intensification of this profitable sector of the economy, a sharp increase in the production of the most valuable food products - eggs and meat. Eimeriosis of birds is widespread in Russia and causes significant damage to the poultry industry, which consists of mortality, retarded growth and development of poultry, losses of meat products and increased feed costs. To combat this invasion, various chemotherapeutic drugs that have an eimecidal effect are used. However, with prolonged use, resistance to them appears. By alternating highly effective anti-eimeriosis drugs, taking into account their properties of activating the immune system, it is possible to extend the period of use of these drugs in the fight against this avian infestation. The material for the research was scrapings of droppings from the floor, bedding, feed, equipment, as well as samples of the blind shoots of dead birds. Many drugs are used without taking into account their long-term effects on the body of birds and, in addition, cause addiction to eimeria, becoming ineffective. The authors have carried out work to improve existing methods for the prevention and treatment of avian eimeriosis using modern coccidiostats, which is of great scientific and practical importance. By using alternation of highly effective anti-eimeriosis drugs, taking into account their properties of activating the immune system, it is possible to extend the period of use of drugs in the fight against bird infestation. Studies have established that the drugs Coccisan in combination with Hydro Rex Vital and Coccidiovit with Amivit tonic have high therapeutic efficacy in spontaneous eimeriosis, 95.0% and 98.0%, respectively. Keywords: poultry farming, chickens, invasions, eimeriosis, contamination, oocyst, prevention, eimeriostasis, pathogen resistance, therapeutic efficacy. References: 1. Aliev A. A. et al. Sravnitelnaya otsenka effektivnosti primeneniya antikoktsidiynykh preparatov Diklafarma i Koktsisana pri koktsidioze tsyplyat-broylerov [Comparative assessment of the effectiveness of the use of anticoccidial drugs Diklapharma and Coccisan for coccidiosis in broiler chickens]. - 2016. 2. Bakrieva R. M. et al. Epizooticheskaya situatsiya po eymeriozam v ptitsevodcheskikh khozyaystvakh v usloviyakh Respubliki Dagestan [Epizootic situation on eimeriosis in poultry farms in the Republic of Dagestan]. - 2013. 3. Demidchik L. G. 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Eymerioz tsyplyat-broylerov [Eimeriosis of broiler chickens]. - 2023. 13. Yagudin A. R. et al. Koktsidioz kur [Coccidiosis of chickens]. - 2021. Author affiliation: Makhieva Bakhu M., Ph.D. in Veterinary Medicine, senior scientific researcher of the Laboratory for the study of invasive diseases of agricultural animals and poultry of the Caspian Zonal Scientific Research Veterinary Institute -branch of the Federal Agrarian Scientific Center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; e-mail: bahumahieva66@gmail.com. Ozdemirova Dzhennet M., Ph.D. in Veterinary Medicine, senior scientific researcher of the Laboratory for the study of invasive diseases of agricultural animals and poultry of the Caspian Zonal Scientific Research Veterinary Institute -branch of the Federal Agrarian Scientific Center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; e-mail: jen167@yandex.ru. Dagaeva Asiyat B., scientific researcher of the Laboratory for the study of invasive diseases of agricultural animals and poultry of the Caspian Zonal Scientific Research Veterinary Institute - branch of the Federal Agrarian Scientific Center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; e-mail: jornal1977@mail.ru. Kabardiev Sadrutdin Sh., D.Sc. in Veterinary Medicine, chief scientific researcher of the Laboratory for the study of parasitic diseases of farm animals and birds of the Caspian Zonal Scientific Research Veterinary Institute - branch of the Federal agricultural scientific center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; e-mail: pznivi05@mail.ru. Responsible for correspondence with the editorial board: Lysenko Aleksandr A., D. Sc. in Veterinary Medicine, professor of the department of therapy and pharmacology of the Kuban State Agrarian University named after I. T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-961-5075415; e-mail: vet.kubgau@mail.ru.
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