Comprehensive study of influence of marek’s disease viruses of serotypes 1 and 3 on expression of IRF7 gene and cellular structure of cross-dominant chickens’ intestinal

УДК 636.5.034:615.371
DOI 10.33861/2071-8020-2023-6-17-20

Tarlavin N. V., Sidorenko K. V., Veretennikov V. V., Dzhavadov E. D., Kraskov D. A.

Summary. Marek’s disease is a dangerous immunosuppressive viral disease of poultry. Every industrial egg poultry farm in the Russian Federation vaccinates against Marek’s disease on the first day of life. Thanks to this vaccine prevention tactic, poultry farms protect themselves from the outbreak of this disease and economic damage. When poultry is infected, this virus causes a significant change in the expression of the immunity gene IRF7. When studying the expression of this gene, a strong effect of viruses of both serotypes on this gene was discovered, with Gallid alphaherpesvirus 2 exceeding the level of this effect compared to the effect of Meleagrid alphaherpesvirus 1 by 4 times. The influence of the Gallid alphaherpesvirus 2 virus was also noted using histological studies: partial destruction of the apical sections of intestinal villi was observed, with loss of integrity of the epithelial lamina, hypertrophy of the lamina propria with noticeable eosinophilia of unknown origin.

Keywords: poultry farming, epizootology, histology, poultry intestine, gene expression, infection, Marek’s disease, virus, serotype.

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Author affliation:

Sidorenko Karina V., Ph. D. in Veterinary Medicine, assistant of the department of biology, ecology and histology of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-931-5346540; e-mail: capricorn26.12.94@yandex.ru.

Veretennikov Vladislav V., Ph. D. in Veterinary Medicine, assistant of the department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8778769; e-mail: vlad.veretennikov.96@mail.ru.

Dzhavadov Eduard D., D. Sc. in Veterinary Medicine, professor of the department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-9666774; e-mail: vnivip1@mail.ru.

Kraskov Dmitry A., postgraduate student of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-4152266; e-mail: kraskov-OO@bk.ru.

Responsible for correspondence with the editorial board: Tarlavin Nikolay V., Ph.D. in Veterinary Medicine, assistant of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8430353; e-mail: tarlav1995@bk.ru.