ÓÄÊ 636.5.034:615.371
DOI 10.33861/2071-8020-2023-6-17-20
Tarlavin N. V., Sidorenko K. V., Veretennikov V. V., Dzhavadov E. D., Kraskov D. A.
Summary. Marek’s disease is a dangerous immunosuppressive viral disease of poultry. Every industrial egg poultry farm in the Russian Federation vaccinates against Marek’s disease on the first day of life. Thanks to this vaccine prevention tactic, poultry farms protect themselves from the outbreak of this disease and economic damage. When poultry is infected, this virus causes a significant change in the expression of the immunity gene IRF7. When studying the expression of this gene, a strong effect of viruses of both serotypes on this gene was discovered, with Gallid alphaherpesvirus 2 exceeding the level of this effect compared to the effect of Meleagrid alphaherpesvirus 1 by 4 times. The influence of the Gallid alphaherpesvirus 2 virus was also noted using histological studies: partial destruction of the apical sections of intestinal villi was observed, with loss of integrity of the epithelial lamina, hypertrophy of the lamina propria with noticeable eosinophilia of unknown origin.
Keywords: poultry farming, epizootology, histology, poultry intestine, gene expression, infection, Marek’s disease, virus, serotype.
References:
1. Dzhavadov E. D. et al. Bolezn Mareka - sovremennoe predstavlenie o bolezni i ee profilaktike [Marek’s disease is a modern understanding of the disease and its prevention]. - Efficient livestock farming. - 2023 (3 (185). - pp. 35-37.
2. Gromov I. N. Patomorfologicheskaya i differentsialnaya diagnostika bolezney ptits, protekayushchikh s preimushchestvennym porazheniem kishechnika [Pathomorphological and differential diagnosis of bird diseases that occur with predominant intestinal damage]. - Animal husbandry and veterinary medicine. - 2020 (2 (37). - pp. 27-31.
3. Dmitriev N. O. et al. Vliyanie kormovoy dobavki na mikromorfometriyu i mikrobiom kishechnika broylerov [Influence of feed additives on the micromorphometry and intestinal microbiome of broilers]. - Agrarian Bulletin of the Urals. - 2023 (2 (231). - pp. 62-70.
4. Tarlavin N. V., Veretennikov V. V., Dzhavadov E. D. et al. Izuchenie ekspressii klyuchevykh genov nespetsificheskogo immunnogo otveta v organizme [Study of the expression of key genes of nonspecific immune response in the body of Gallus gallus domesticus under the influence of infection with immunosuppressive vaccine viruses]. - International Bulletin of Veterinary Medicine. - 2022 (4). - pp. 34-41.
5. Kuleshov K. A. Postnatalnyy morfogenez organov zheludochno-kishechnogo trakta kur pri primenenii selensoderzhashchikh preparatov [Postnatal morphogenesis of the gastrointestinal tract of chickens when using selenium-containing drugs]. - Veterinary pathology. - 2010 (1 (32). - pp. 57-66.
6. Rusakova E. A. Otsenka morfofunktsionalnogo sostoyaniya tonkogo otdela kishechnika tsyplyat-broylerov pri vvedenii fitazy v ratsion [Assessment of the morphofunctional state of the small intestine of broiler chickens with the introduction of phytase into the diet]. - News of the Orenburg State Agrarian University. - 2017 (6 (68). - pp. 138-141.
7. Tarlavin N. V. Immunogennye svoystva immunokompleksnoy vaktsiny protiv infektsionnoy bursalnoy bolezni [Immunogenic properties of an immunocomplex vaccine against infectious bursal disease]. - 2022: 142 p.
8-14. Vide supra.
Author affliation:
Sidorenko Karina V., Ph. D. in Veterinary Medicine, assistant of the department of biology, ecology and histology of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-931-5346540; e-mail: capricorn26.12.94@yandex.ru.
Veretennikov Vladislav V., Ph. D. in Veterinary Medicine, assistant of the department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8778769; e-mail: vlad.veretennikov.96@mail.ru.
Dzhavadov Eduard D., D. Sc. in Veterinary Medicine, professor of the department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-9666774; e-mail: vnivip1@mail.ru.
Kraskov Dmitry A., postgraduate student of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-4152266; e-mail: kraskov-OO@bk.ru.
Responsible for correspondence with the editorial board: Tarlavin Nikolay V., Ph.D. in Veterinary Medicine, assistant of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8430353; e-mail: tarlav1995@bk.ru.
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