Specific prevention of adenoviral infection of cattle with combined vaccine

Shemelkovа G.O., Verkhovskaya A.E., Soboleva G.L.,
Shemelkov E.V., Ivanov E.V., Nepoklonova I.V., Aliper T.I.

Summary. According to the monitoring of serum samples presence of specific antibodies to bovine adenovirus was revealed in 24% of samples, suggesting widespread of adenovirus infection. For the prevention of major respiratory and enteric diseases of calves seven-component combined vaccine including bovine adenovirus type 1 has been developed. Vaccine has been successfully tested in cattle farms with major infectious diseases of calves.

Key words: adenovirus, viral infections, cattle, adjuvants, vaccine, antigene activity, efficiency, prevention.

References:

1. Belousova R.V. Laboratornaya diagnostika i spetsificheskaya profilaktika adenovirusnoy infektsii krupnogo rogatogo skota [Laboratory diagnostics and specific prophylaxis of bovine adenoviral infection]. – Moscow, 1989.

2. Vazir Ya. Tekhnologiya prigotovleniya i antigennye svoystva assotsiirovannoy inaktivirovannoy vaktsiny protiv adenovirusnoy infektsii i virusnoy diarei krupnogo rogatogo skota [Preparation technology and antigenic properties of associated inactivated vaccine against bovine adenoviral infection and diarrhea virus]. – Moscow, 2008.

3. Petrov R.V., Khaitov R.M. Immunogeny i vaktsiny novogo pokoleniya [Immunogens and new generation vaccines]. – Moscow, 2011.

4. Lobova T.P. Usovershenstvovanie laboratornoy diagnostiki adenovirusnoy infektsii krupnogo rogatogo skota [Improvement of laboratory diagnosis of adenoviral bovine infection]. – Moscow, 2006.

5. Syurin V.N. Virusnye bolezni zhivotnykh [Viral animal diseases]. – Moscow, 1998. – p. 770.

6. Shemelkova G.O., Yuzhakov A.G., Soboleva G.L., Koritskaya M.A., Shemelkov E.V., Ivanov E.V., Aliper T.I. Vydelenie i biologicheskie svoystva adenovirusa krupnogo rogatogo skota 1-go tipa [Isolation and biological properties of bovine adenovirus 1 type]. – Veterinariya. – Moscow, 2013 (4). – pp. 8-11.

7. Yurov K.P., Shulyak A.F. Profilaktika infektsionnykh bolezney telyat [Prophylaxis of infectious diseases of calves]. – Irkutsk, 2001. – pp. 9-10.

8. Aldasy P. Pneumoenteritic in calves caused by adenoviruses / P.Aldasy, A.Bartha//Acta. Vet. Hung.- 1965.-V. 15.-P. 167-175.

9. Edwards T.A. Control methods for bovine respiratory disease for feedlot cattle./T.A. Edwards/ Vet Clin. North Am. Food Anim Pract. 2010 Jul;26(2):273-84.

10. Fulton R.W. Bovine respiratory disease research (1983-2009)./ R.W. Fulton/ Anim Health Res Rev. 2009 Dec;10(2):131-9.

11. Rondhuis P.R. Bovine adenoviruses. A review of vaccination experiments. /P.R. Rondhuis / Dev Biol Stand. 1975; 28:493-500.

Author affiliation:

Shemelkova Galina O., biotechnologist of the department of quality control of the Vetbiochem LLC; 16, Gamaleya st., Moscow, 123098; phone: +7 (495) 193-54-93; e-mail: shemelckova@yandex.ru.

Verkhovskaya Anna E., Ph.D. in Veterinary Medicine, deputy chief of the department of quality control of the Vetbiochem LLC; 16, Gamaleya st., Moscow, 123098; phone: +7 (495) 193-54-93; e-mail: averkchovskay@mail.ru.

Soboleva Galina L., D.Sc. in Biology, head of the department of quality control of the Vetbiochem LLC; 16, Gamaleya st., Moscow, 123098; phone: +7 (495) 193-54-93; e-mail: gsoboleva@rosvet.ru.

Ivanov Evgeny V., Ph.D. in Biology, leading scientific researcher of the Diagnostic and Prevention Research Institute for Human and Animal Diseases; 16, Gamaleya st., Moscow, 123098; phone: +7 (499) 190-75-61; e-mail: doctor2112@yandex.ru.

Nepoklonova Irina V., Ph.D. in Veterinary Medicine, manager of the department of diagnostics and prevention of virus diseases of the Diagnostic and Prevention Research Institute for Human and Animal Diseases; 16, Gamaleya st., Moscow, 123098; phone: +7 (499) 190-75-61; e-mail: info@dpri.ru.

Aliper Taras I., D.Sc. in Biology, professor, director of the NARVAC Ltd; head of the department of applied virology and biotechnology of Ivanovsky Research Institute of Virology; 16, Gamaleya str., Moscow, 123098; phone: +7 (499) 190-30-54; e-mail: aliper@narvac.com.

Responsible for correspondence with the editorial board: Shemelkov Evgeny V., Ph.D. in Veterinary Medicine, leading scientific researcher of the Diagnostic and Prevention Research Institute for Human and Animal Diseases (DPRI); 16, Gamaleya st., Moscow, 123098; phone: +7 (499) 190-75-61; e-mail: shemelkov@mail.ru.