UDC 579.62:619.57.083.1 Droshnev A.E., Zavyalova E.A., Gulyukin M.I. Summary. Vibriosis is the large scale bacterial disease of fishes, shellfishes, crustacean, grown in the saltish and sea water. Increasing production volumes and, accordingly, fish-holding densities and the number of commercial units in local water areas cause the growing pressing of pathogenic microorganisms, lately causing epizootic diseases. Same factors do not allow to perform the 100% antibiotic therapy of the whole livestock, what causes the development of the antibiotic resistance of circulating strains, as well as reiterate onsets of epizootic diseases. The world practice of fighting against vibriosis consists in the blanket vaccination, for which nowadays many methods have been developed: baths, oral application, injections. This article comprises materials on the vaccine use against vibriosis at the commercial farm. Series of field experiences have established that bacterin baths are not efficient enough; the adjuvant enhances the protection up to 90-97% of the fish livestock, but has got shortages as well, for example, the oil adjuvant is poorly tolerated by fishes due to the local inflammatory reaction. For the industrial production it is recommended to select components, combining the decent protection level, but not causing such side effects as the aluminium hydroxide. Key words: disease of salmon fish, rainbow trout, vibriosis, vibrio, vaccine, virulence, immunogenicity, biologics, antigen activity, adjuvant. References: 1. Bezgachina T.V. Problemy zdorovya ryb pri kultivirovanii ikh v sadkakh [Problems of fish health at cultivation in cages]. - 2014. - pp. 22-26. 2. Vismanis K.O. Profilaktika i lechenie ryb pri akvakulture [Prevention and treatment of fish in aquaculture]. - 1980. - pp. 37-39. 3. Gulyukin M.I., Zavyalova E.A., Droshnev A.E., Kolomytsev S.A. Analiz epizooticheskoy situatsii po boleznyam ryb v Rossii [Analysis of the epizootic situation of fish diseases in Russia]. - Veterinariya. - Moscow, 2011 (8). - pp. 3-7. 4. Droshnev A.E., Zavyalova E.A. Konstruirovanie vaktsinnogo preparata protiv vibrioza lososevykh ryb [Construction of vaccine against vibriosis of salmon fish]. - Trudy VNIIEV. - Moscow, 2013 (77). - pp. 234-238. 5. Droshnev A.E., Zavyalova E.A., Bogdanova P.D., Bulina K.Yu. Razrabotka sovremennogo metoda zashchity zdorovya lososevykh ryb - vaktsiny protiv vibrioza [Development of modern method - vaocine against vibriosis - for protecting health of salmonids]. - 2016. - pp. 408-413. 6. Droshnev A.E., Zavyalova E.A., Gulyukin M.I., Khlunov O.V. Sovremennaya vaktsinoprofilaktika raduzhnoy foreli protiv vibrioza [Modern vaccine prevention of rainbow trout against vibriosis]. - Rossiyskiy veterinarnyy zhurnal. - Moscow, 2012 (1). - pp. 31-33. 7. Droshnev A.E., Zavyalova E.A., Khlunov O.V. Razrabotka novykh i sovershenstvovanie primenyaemykh metodov profilaktiki vibrioza lososevykh ryb [Development of new and improvement of existing prevention methods of vibriosis of salmonids]. - Orenburg, 2012. - pp. 341-345. 8. Droshnev A.E., Zavyalova E.A., Khlunov O.V. Vidovoe raznoobrazie galofilnykh vibrionov Belogo morya i ikh epizooticheskaya znachimost [Species diversity of halophilic vibrioids of the White Sea and their epizootic significance]. - 2011: 78-80. 9. Zavyalova E.A., Droshnev A.E. Specificheskaya profilaktika vibrioza lososevykh ryb: neobkhodimost i perspektivy [Specific prevention of vibriosis of salmonids: necessity and prospects]. - 2016: 356-357. 10. Sposob polucheniya inaktivirovannoy vaktsiny protiv vibrioza ryb [Process for preparing an inactivated vaccine against vibriosis fish]. - Patent 2284830. - Moscow, 2006. -p. 6. 11. Inaktivirovannaya vaktsina protiv vibrioza ryb [Inactivated vaccine against vibriosis fish]. - Patent 2284831. - Moscow, 2006. - p. 4. 12-16. Vide supra. Author affiliation Droshnev Aleksey E., Ph.D. in Biology, senior researcher of the laboratory of ichthyopathology of the All-Russian Research Institute for Experimental Veterinary Medicine named by Ya.R. Kovalenko; 24-1, Ryazansky av., Moscow, 109428; phone: 8-495-995-88-61; e-mail: asdf1961@mail.ru. Gulyukin Mikhail I., D.Sc. in Veterinary Medicine, professor, director of the All-Russian Research Institute for Experimental Veterinary Medicine named by Ya.R. Kovalenko; 24-1, Ryazansky av., Moscow, 109428; phone: 8-495-970-03-69; e-mail: admin@viev.ru. Responsible for correspondence with the editorial board: Zavyalova 23 Elena А., Ph.D. in Biology, head of the laboratory of ichthyopathology of the All-Russian Research Institute for Experimental Veterinary Medicine named by Ya.R. Kovalenko; 24-1, Ryazansky av., Moscow, 109428; phone: 8-495-995-88-61; e-mail: aquazeda@mail.ru.
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