Somatotropic hormone production stimulation in lambs and piglets at Gamavit use

UDC 619:615.37:636.32/.38

Sanin A.V., Deeva A.V., Narovlyanskiy A.N., Pronin A.V., Kozhevnikova T.N., Sanina V.Yu., Timofeeva T.Yu., Annikov V.V., Kudinov A.V., Annikova L.V., Larina E.A.

Summary. Previously it was shown that Gamavit induced increase in the somatotropic hormone (STH) blood level in calves. Authors studied Gamavit influence on the STH blood level in lambs and piglets. Studies were carried out in the farms of Saratov region on newborn lambs of the Stavropol breed and Landrace piglets at the age of 5 days with a live weight of 2.5 kg. Gamavit was injected to lambs at a dose of 0.5 ml / kg of body weight intramuscularly every 7, 14 and 21 days after birth; piglets – in the same dose three times in the 5th, 7th and 9th day of life in a day in the evening. During the experiment, significant changes in the dynamics of hematological parameters and leukogram lambs injected with gamavit were not observed. Using enzyme immunoassay we showed that in lambs Gamavit i.m. injection at a dose of 0.5 ml per 1 kg of live weight upon 7, 14 and 21 days after birth led to the increase of STH blood level up to 11.7 – 13.1 mMU/l (compared with 6.7 mMU/l in control) in 2 – 3 weeks. In the newborn piglets 3 injections of Gamavit at the same dose led to 2.7-times increase of STH blood level. At the age of 28 days the gain of live body weight in piglets treated with Gamavit was about 600 g per 1 head in comparison with the control.

Keywords: lambs, piglets, immunomodulator, Gamavit dose, blood sample, hematology, growth hormone, safety of young animals, feed consumption.

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Author affiliation:

Sanin Aleksandr V., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Deeva Anna V., Ph.D. in Medicine, veterinarian of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Narovlyanskiy Aleksandr N., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Pronin Aleksandr V., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Sanina Valentin Yu., Ph.D. in Chemistry, Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Timofeeva Tatiana Yu., scientific researcher of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: info@riem.ru.

Annikov Viacheslav V., D.Sc. in Veterinary Medicine, professor of the department of animal diseases and veterinary sanitary expertise of the Vavilova Saratov State Agrarian University; 1, Teatralnaia sq., Saratov, 410012; phone: 8(917)0246405; e-mail: rector@sgau.ru.

Kudinov Aleksandr V., Ph.D. in Veterinary Medicine, professor of the department of animal diseases and veterinary sanitary expertise of the Vavilova Saratov State Agrarian University; 1, Teatralnaia sq., Saratov, 410012; phone: 8(960)3432216; e-mail: rector@sgau.ru.

Annikova L.V., Ph.D. in Veterinary Medicine, professor of the department of animal diseases and veterinary sanitary expertise of the Vavilova Saratov State Agrarian University; 1, Teatralnaia sq., Saratov, 410012; e-mail: rector@sgau.ru.

Larina E.A., chief veterinarian of Kulikovo Ltd.; 136, Sovetskaia st., Kulikovka vllg., Volskii district, Saratov region, 412958; phone: 8 (917) 9858544.

Responsible for correspondence with the editorial board: Kozhevnikova Tatiana N., Ph.D. in Medicine, Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8(499)1905851; e-mail: tatiana@micro-plus.ru.