Selection of components at RST-10 immunomodulator development and its immunogenic properties

УДК: 619:579.834.115
DOI 10.33861/2071-8020-2024-6-16-18

Staroselov M. A., Kopylov D. V., Skhatum A. K., Yakovets M. G., Gorpinchenko E. A., Ponomarenko V. A

Summary. One of the key tasks in the development of animal husbandry is to ensure well-being in the fight against infectious diseases. The species composition of microorganisms isolated from bronchopneumonia patients and healthy calves at the age of 3-4 months was determined. An immunomodulator obtained from bacterial lysates of the 10 most common microorganisms in diseased calves with bronchopneumonia was designed. Immunogenic properties of immunomodulator RST-10, for treatment and prevention of respiratory diseases of young cattle, were studied on mongrel white mice. The research work was carried out on the basis of the department of therapy and obstetrics. It was found that the immunogenic activity of the preparation RST-10 was the highest in the dosage of 0.2 mg/kg body weight. The analysis of the results of the effect of RST-10 preparation sample on the live body weight of experimental rats shows that the maximum weight increase of 33.8% (64.89 g.).

Keywords: calves, microflora, bronchopneumonia, immunomodulator, pure culture, immunology, cattle, respiratory organs, bacterial lysates.

Author affiliation:

Kopylov Danila V., postgraduate student of the Department of Therapy and Obstetrics of the Krasnodar Scientific Center for Animal Husbandry and Veterinary Medicine; 1, 1 Liniya st., Krasnodar, 350004.

Skhatum Aminet K., Ph. D. in Veterinary Medicine, leading scientific researcher of the Department of Therapy and Obstetrics of the Krasnodar Scientific Center for Animal Husbandry and Veterinary Medicine; 1, 1 Liniya st., Krasnodar, 350004; phone: 8-918-4725784; e-mail: knivitherapy@gmail.com.

Yakovets Margarita G., junior scientific researcher of the Department of Therapy and Obstetrics of the Krasnodar Scientific Center for Animal Husbandry and Veterinary Medicine; 1, 1 Liniya st., Krasnodar, 350004.

Gorpinchenko Evgeny A., Ph.D. in Veterinary Medicine, docent of the department of therapy and pharmacology of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-861-2215820; e-mail: gorpinchenko.e@kubsau.ru.

Ponomarenko Veronika A., student of the Kuban State Agrarian University named after I. T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-900-2601656; e-mail: knivitherapy@gmail.com.

Responsible for correspondence with the editorial board: Staroselov Mikhail A., Ph. D. in Veterinary Medicine, Head of the Department of Therapy and Obstetrics of the Krasnodar Scientific Center for Animal Husbandry and Veterinary Medicine, docent of the Department of Microbiology, Epizootology and Virology of the Kuban State Agrarian University named after I. T. Trubilin; 1, 1 Liniya st., Krasnodar, 350004; phone: 8-953-1122803; e-mail: knivitherapy@gmail.com.