Identification of large horned cattle at latent course of tuberculosis

UDC 619:579.872.21

Makarov Iu. A., Gorkovenko N. E.

Summary. Transition of a disease to a chronic or latent form is promoted by the microorganisms keeping viability in tissues of animals. This phenomenon is designated by the term persistence. Usually microorganism persistence is noted in the L-shaped forms. Almost all microbes can form L-shaped forms and close to them variants of bacteria in macroorganism, allowing them to persist for a long time in the host organism, while retaining the possibility of reversion to the original bacterial species. The problem of a persistence of mycobacteria is reviewed in the article. Latent tuberculosis infection represents a serious danger, since under the influence of environmental factors, latent infection can go into a progressive active tuberculosis. In addition, it creates certain difficulties for the detection infected animals during allergic diagnostics of bovine tuberculosis. The purpose of the study was to improve the accuracy of diagnostics of a tuberculosis, intravital timely identification of cattle with a hidden passage of tuberculosis infection by allergic diagnostics. Studies on phagocytic activity of blood leucocytes and cytochemical research on myeloperoxidase were carried out in the indicator groups of animals before the allergic diagnostics of tuberculosis. It was found that at the certain level of the immune status the animal organism gives more complete response to the allergen, which allows to identify large horned cattle with the latent course of

tuberculosis infection.

Key words: tuberculosis, Mycobacterium spp., persistence, L-shaped forms, allergic diagnostics, indicator group, phagocytosis, index of phagocytosis completeness, myeloperoxidase, cytochemical factor.

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Author affiliation:

Makarov Iury A., D.Sc. in Veterinary Medicine, professor, Academician of the Russian Academy of Sciences, professor of the department of microbiology, epizootology and virology of the Kuban State Agrarian University; 13, Kalinina st., Krasnodar, 350044; e-mail: prof-makarov@mail.ru.

Responsible for correspondence with the editorial board: Gorkovenko Natalya E., D.Sc. in Biology, professor of the department of applied ecology of the Kuban State Agrarian University; 13, Kalinina st., Krasnodar, 350044; phone: 8-962-861-99-72; e-mail: gorkovenko-n@mail.ru.