Metabolic disorders in highly productive cows at acute postpartum endometritis

DOI 10.33861/2071-8020-2019-5-3-5

Petrov K.I., Orzhekhovsky S.A., Zabolotnykh M.V., Zhernosenko A.A., Konvay V.D.

Summary. In modern dairy farming, highly productive cows imported from abroad are widely used. When released into the farms of Western Siberia, they often develop metabolic disorders, leading to the premature culling of these animals. The mechanism of their development is not fully understood, which limits the development of new methods of prevention of treatment. In this paper, we studied the mechanisms of metabolic disorders in highly productive cows with acute postpartum endometritis. The studies were conducted on Holstein cows in one of the farms in the Isetsky district of the Tyumen region, in which acute postpartum endometritis developed on the 5-7th day of the postpartum period. Along with the study of the clinical state of animals directly into blood was determined ESR, hemoglobin, erythrocytes, leukocytes, glucose and the plasma it - the concentration of protein, urea, uric acid, p-hydroxybutyric acid, cholesterol, activity alaninaminotranferazy, aspartate aminotransferase, lactate dehydrogenase and alkaline phosphatase. It has been established that on the fifth to seventh days of the postpartum period, cows of the heifers who have suffered generic weakness develop acute postpartum endometritis, manifested in an increase in the erythrocyte sedimentation rate, leukocyte count, and plasma protein content. The development of this disease is accompanied by an increased level of ketone bodies in the tissues against the background of a decrease in blood levels of hemoglobin, erythrocytes and hematocrit, contributing to increased purine catabolism associated with excessive production of active oxygen metabolites. At the same time, cows have not yet expressed serum syndrome of hepatocellular insufficiency, but hepatocyte integrity disorders have already been observed, manifested in an increase in the activity of enzymes in the blood plasma, especially alanine aminotransferase.

Keywords: highly productive cows, postpartum endometritis, metabolic disorders, anemia, impaired integrity of hepatocytes.

Author affiliation:

Orzhekhovsky Sergey A., post-graduate student of the Department of diagnostics, internal non-contagious diseases, pharmacology, surgery and obstetrics of the Omsk State Agrarian University named after P.A. Stolypin; 8/1, Dobrovolskogo, Omsk, 644122.

Zabolotnykh Mikhail V., professor of the Department of veterinary-sanitary expertise of livestock products and hygiene of farm animals of the Omsk State Agrarian University named after P.A. Stolypin; 92, Oktyabrskaya st., Omsk, 644122; e-mail: zabolotnykh@omgau.org.

Zhernosenko Alexander A., docent of the Department of diagnostics, internal non-contagious diseases, pharmacology, surgery and obstetrics of the Omsk State Agrarian University named after P.A. Stolypin; 92, Oktyabrskaya st., Omsk, 644122; phone: 8-3812-230392; e-mail: zhernosenko@yandex.ru.

Konvay Vladimir D., professor of the Department of medical-prophylactic faculty, Department of biochemistry of the Omsk State Medical University; 92, Oktyabrskaya st., Omsk, 644122; e-mail: konway@omgau.org.

Responsible for correspondence with the editorial board: Petrov Konstantin I., post-graduate student of the Department of diagnostics, internal non-contagious diseases, pharmacology, surgery and obstetrics of the Omsk State Agrarian University named after P.A. Stolypin; 8/1, Dobrovolskogo, Omsk, 644122; phone: 8-902-9841514; e-mail: pk-89@mail.ru.