Antibiotics and bacteriophages combined action in therapeutic tactics

УДК 619:615.33:619:578.81
DOI 10.33861/2071-8020-2023-4-39-41

Laishevtsev A. I., Shastin P. N., Khabarova A. V., Savinov V. A., Pimenov N. V.

Summary. Due to widespread antibiotics usage, there are currently bacteria all over the world that have acquired multidrug resistance and, as a result, the question arises of finding an alternative treatment. Bacteriophages are a promising direction in this matter. Bacteriophages are used to fight infections caused by resistant pathogens. However, this does not indicate a complete replacement of antibiotics in treatment, but suggests the combined use of bacteriophages and antibiotics. The enhancement of antibiotic effect by phages leads to a more effective treatment of biofilm infections, and the symbiotic effect can also lead to a decrease in the development of resistance to phages and antibiotics. Despite a number of advantages that have been proven by experimental data, it is worth noting that this concept of treatment also has negative aspects. In any case, it is necessary to carefully select the combination of a bacteriophage and an antibiotic for a symbiotic effect on microorganisms. Most commonly combined antibacterial therapy is used against such bacterial infectious agents as Pseudomonas aeruginosa, as well as a number of other organisms such as Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Enterococcus faecalis, and Burkholderia cepacia. The study of the symbiotic effect of the listed group reflects the positive effect of combined treatment. This review presents an analysis of current research on the symbiosis of bacteriophages and antibiotics on pathogens in order to modify standard treatment regimens as well as to propose fundamentally new methods in the fight against multidrug-resistant strains.

Keywords: antibiotics, phages, antibiotic and phage combination, antibacterial drug resistance, synergetic effect, antibiotics and phages combined effect, multi-drug resistant strains, DNA containing viruses, Staphylococcus aureus, antibacterial therapy.

References:

1. Gorshkova A.S., Drwker V.V., Sykilinda N.N. The Combined Effect of Bacteriophages and Antibiotics on Pseudomonas aeruginosa Biofilm // Antibiotics and Chemotherapy. - 2020. - № 65 (3 - 4). - P. 7 - 11. (In Russ.)

2-15. Vide supra.

Author affiliation:

Laishevtsev Aleksey I., Ph. D. in Biology, head of the laboratory of the All-Russian Research Institute of Experimental Veterinary Medicine named after K. I. Scryabin and Ya. R. Kovalenko of the Russian Academy of Sciences; participant of the Evolink project of Microecology LLC; 1, 24, Ryazansky av., Moscow, 109428; e-mail: a-laishevtsev@bk.ru.

Shastin Pavel N., Ph. D. in Veterinary Medicine, senior scientific researcher of the All-Russian Research Institute of Experimental Veterinary Medicine named after K. I. Scryabin and Ya. R. Kovalenko of the Russian Academy of Sciences; 1, 24, Ryazansky av., Moscow, 109428.

Khabarova Alla V., scientific researcher of the All-Russian Research Institute of Experimental Veterinary Medicine named after K. I. Scryabin and Ya. R. Kovalenko of the Russian Academy of Sciences; 1, 24, Ryazansky av., Moscow, 109428.

Savinov Vasily A., scientific researcher of the All-Russian Research Institute of Experimental Veterinary Medicine named after K. I. Scryabin and Ya. R. Kovalenko of the Russian Academy of Sciences; 1, 24, Ryazansky av., Moscow, 109428.

Responsible for correspondence with the editorial board: Pimenov Nikolay V., D.Sc. in Biology, Head of the Department of Immunology and Biotechnology of the Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K.I. Skryabin; participant of the Evolink project of Microecology LLC; 23, Akademika Skryabina st., Moscow, 109472; phone: 8-968-5103585; e-mail: pimenov-nikolai@yandex.ru.