Post-vaccine complications problems of in immunized animals

УДК 619:616.98:578
DOI 10.33861/2071-8020-2023-4-14-17

Krivonos R. A., Chernykh O. Yu., Mishchenko V. A., Mishchenko A. V., Chernov A. N.

Summary. Vaccine prevention is one of the greatest achievements of mankind, influencing the reduction of the incidence of infectious diseases and the mortality caused by them. World experience convincingly shows that the most effective way to protect against pathogens of infectious diseases is vaccination. Vaccination occupies a leading place in the fight against many animal infections and is the most widespread form of veterinary intervention, affecting almost every domestic animal. To prevent infectious diseases of farm animals, inactivated mono- and polyvalent (sorbed and emulsion) and live (from homologous or heterologous pathogens) virus vaccines are widely used. The issue of vaccine safety and vaccination is considered simultaneously with the immunological effectiveness of immunobiological drugs. Currently, there are no absolutely safe vaccines that do not cause adverse reactions. A number of researchers believe that it is impossible to completely avoid the appearance of post-vaccination pathologies in the body of a vaccinated animal, including abortions and embryonic mortality. At the same time, it is known that the damage from infectious diseases significantly exceeds the damage from vaccination. Of particular importance is the vaccination of animals in border buffer zones against trans-border infections to prevent the introduction of foot-and-mouth disease pathogens, infectious nodular dermatitis of cattle and peste des petits ruminants from neighboring countries.

Key words: large horned cattle, small horned cattle, pigs, vaccination, virus vaccines, allergic reactions, allergenicity, anaphylaxis, contaminating viruses, post-vaccination complications, cell culture, anaphylactic shock, endotoxic shock, antibacterial drugs, cross-border infections, buffer zone.

Author affiliation:

Krivonos Roman A., Ph.D. in Veterinary Medicine, docent of the department of parasitology, veterinary-sanitary expertise and animal hygiene of the Kuban State Agrarian University named after I. T. Trubilin; 13, Kalinina st., Krasnodar, 350044; e-mail: uv@krasnodar.ru.

Mishchenko Vladimir A., D.Sc. in Veterinary Medicine, professor, chief scientific researcher of the Laboratory of the prevention of diseases of pigs and horned cattle of the Federal Centre of Animal Health; mcrd. Yurjevets, Vladimir, Russia, 600901; phone: 8-4922-261551; e-mail: mishenko@arriah.ru.

Mishchenko Aleksey V., Ph.D. in Veterinary Medicine, senior scientific researcher of the information analysis center of the Federal Centre of Animal Health; mcrd. Yurjevets, Vladimir, Russia, 600901; phone: 8-4922-261551; e-mail: a.mischenko@mcx.ru.

Chernov Albert N., D.Sc. in Biology, docent, deputy director for research of the Krasnodar Scientific Center for Animal Husbandry and Veterinary Medicine; 1, 1 Liniya st., Krasnodar, 350004; phone: 8-927-4036300; e-mail: rt-kazan@mail.ru.

Responsible for correspondence with the editorial board: Chernykh Oleg Yu., D.Sc. in Veterinary Medicine, docent, professor 17 of the Department of microbiology, epizootology and virology of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-918-4956659; e-mail: gukkvl50@kubanvet.ru.