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УДК 578.832.1 DOI 10.33861/2071-8020-2023-4-3-5 Tarlavin N.V., Veretennikov V.V., Dzhavadov E.D., Kraskov D.A., Berezkin V.A. Summary. The influenza A virus, which causes high- and low-pathogenic influenza in most species of farm birds, is today the biggest problem for the domestic poultry industry. One of the reasons for the danger of this disease lies in the ability of the pathogen to various forms of reassortment and recombination, which in turn is possible thanks to the segmented genome, which consists of 8 separate segments. In this study, we set a goal to find out how genetically different the 5th and 7th segments of the influenza A virus genome (traditionally considered identical) of subtypes H5N1, H7N9 and H9N2 are genetically different from each other, for which we compared different sequences of virus isolates of the above subtypes. The results of the study showed that the 7th segment of the genome of the H5N1 virus differs from its homologues in the H9N2 and H7N9 viruses by 9.7% and 11.3%, respectively. The 5th segment of the H5N1 virus genome differs from the homologous segments of the above-mentioned viruses by 12.4% and 9.2%, respectively. Thus, there is a clear genetic difference between these segments in different subtypes of the virus. Keywords: poultry farming, highly pathogenic avian influenza, influenza A virus, genome, strain, H5N1, H7N9, H9N2, outbreak, outbreak. References: 1. Andreychuk D. B., Shcherbakova L. O., Guseva N. A. et al. Aktualnye virusnye infektsii v ptitsevodstve: analiz rezultatov molekulyarnoy diagnostiki [Current viral infections in poultry farming: analysis of molecular diagnostic results]. - 2021. -Vol. 82. - pp. 51-57. 2. Dzhavadov E. D., Dmitrieva M. E. Gripp ptits [Bird flu]. - 2011. - 188 p. 3. Larionova N. V. Vozbuditel grippa: izmenchivost v prirode i eksperimente [Causative agent of influenza variability in nature and experiment]. - 2017: 22. 4-8. Vide supra. Author affliation: Veretennikov Vladislav V., Ph. D. in Veterinary Medicine, assistant of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8778769; e-mail: vlad.veretennikov.96@mail.ru. Dzhavadov Eduard D., D. Sc. in Veterinary Medicine, professor of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-9666774; e-mail: vnivip1@mail.ru. Kraskov Dmitry A., postgraduate student of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-921-4152266; e-mail: kraskov-OO@bk.ru. Berezkin Vladislav A., Ph. D. in Veterinary Medicine, veterinary epizootologist of the Saint-Petersburg City Station for Animal Disease Control; 46, 2-ya Zhernovskaya st., Saint-Petersburg, 195043; phone: 8-911-2942098; e-mail: berezki.v@yandex.ru. Responsible for correspondence with the editorial board: Tarlavin Nikolay V., Ph.D. in Veterinary Medicine, assistant of the Department of epizootology named after V.P. Urban of the St. Petersburg State University of Veterinary Medicine; 5, Chernigovskaya st., Saint-Petersburg, 196084; phone: 8-981-8430353; e-mail: tarlav1995@bk.ru.
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