V.S. Kaplin, O.N. Kaplina
Summary. Normal microbial populations present in the intestines of farm animals provide an effective barrier against the invasion of pathogenic microorganisms. Protection mechanisms include competition for nutrients and adhesion sites, production of antimicrobial compounds, and stimulation of the immune system. Imbalance in this natural bacterial consortium can lead to undesirable consequences. Therefore, monitoring the bacterial balance in the intestines of farm animals is very important in terms of limiting the risk of infection. The easiest way to influence the growth of a population of bacteria is the use of antibiotics. However, in January 2006, the European Union banned the use of livestock antibiotics. Therefore, in the animal feed industry, approaches and principles for modulating microflora in the gastrointestinal tract of animals must be developed. The use of IgY-technologies allows to selectively limit the growth of pathogenic or undesirable bacteria, without affecting normal microbial populations. This review focuses on the use of IgY in the therapy or prevention of diseases in veterinary medicine.
Keywords: immunoglobulins, IgY, passive immunization, cow mastitis, rotavirus diarrhea, salmonellosis, avian influenza, coccidiosis, parvovirus, infectious bursitis, white spot syndrome virus.
1. Verkhovskiy O.A., Aliper T.I., Chernykh O.Yu., Nepoklonov E.A. Strategiya immunoterapii i perspektivy ispolzovaniya poliklonalnykh antitel v klinicheskoy praktike (obzor) [Immunotherapy strategies and prospects of polyclonal antibodies' use in clinical practice (review)]. - Veterinaria Kubani. - Krasnodar, 2016 (6). - pp. 3-7.
2. Kaplin V.S., Kaplina O.N. IgY-tekhnologii. Zheltochnye antitela ptits [IgY-technologies. Avian yolk antibodies]. - Biotekhnologiya. - Moscow, 2017 (2). - pp. 29-40.
3-39. Vide supra.
Kaplina Olga N., senior scientific researcher of the State scientific Centre of virology and biotechnology «Vector»; Koltsovo, Novosibirsk region, 630559; e-mail: firstname.lastname@example.org.
Responsible for correspondence with the editorial board: Kaplin Vladimir S., Ph. D. in Biology, senior scientific researcher of the State scientific Centre of virology and biotechnology «Vector»; Koltsovo, Novosibirsk region, 630559; e-mail: email@example.com.