Gamavit efficacy in treatment of borreliosis in dogs

UDC: 619:616.9:615.24.015.4:636.7

Annikov V.V., Annikova L.V., Sanin A.V, Narovlyansky А.№, Pronin A.V., Sanina V.Yu., Kozhevnikova T.N.

Summary. The work is devoted to the evaluation of Gamavit effectiveness in the treatment of borreliosis in dogs. Gamavit has proven clinical efficacy in the treatment of infections and parasitic infestations in pets. The justification for its inclusion into the therapeutic protocol was based on the data that the use of antibiotics can cause mass death of spirochetes, accompanied by the release of endotoxins in the blood and aggravation of the clinical condition of the patient. The study was performed on 12 dogs divided into 2 equal groups according to the principle of analogues. The diagnosis was made on the basis of the blood sera IHA studies. Doxycycline (10 mg/kg for a week) was administered as an etiotropic drug, complemented by Rimadil. Patients of the second group were additionally inoculated with Gamavit (0.2 ml per kg, s/c, once a day for 5 days). Results of treatment showed that Lime borreliosis of dogs in the Saratov region is accompanied to a greater extent by nephritis and arthrosis. Inclusion of Gamavit in the treatment protocol allows weakening the inflammatory response and preventing kidney damage. Clinically, after a week of therapy, normalization of temperature, disappearance of polyuria, weakening of lameness were noted. In hematological study, decline in erythrocyte sedimentation rate was observed as well as decreased leukocytosis and eosinophilia. Biochemical studies of the blood serum showed decreased inflammatory response in dogs of the 2nd group. Thus, Gamavit increases the of borreliosis treatment.

Keywords: borreliosis, dogs, Lyme disease, gamavit, Ixodes ticks, spirochetes, doxycycline, nephritis, arthritis, keratitis.

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Author affiliation:

Annikov Vyacheslav V., D.Sc. in Veterinary Medicine, professor of the department of animal diseases and veterinary sanitary expertise of the Vavilov Saratov State Agrarian University; 1, Teatralnaya sq., Saratov, 410012; phone: 8917-024-64-05; e-mail: vetdoc-annikov@mail.ru.

Annikova Lyudmila V., Ph.D. in Veterinary Medicine, docent of the department of animal diseases and veterinary sanitary expertise of the Vavilov Saratov State Agrarian University; 1, Teatralnaya sq., Saratov, 410012; phone: 8-917-314-10-90; e-mail: alaw67@inbox.ru.

Sanin Aleksandr V., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8-499-193-43-55; e-mail: saninalex@inbox.ru.

Narovlyanskiy Aleksandr N., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8-499-193-43-06; e-mail: narovl@yandex.ru.

Pronin Aleksandr V., D.Sc. in Biology, professor of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8-499-190-57-41; e-mail: proninalexander@yandex.ru.

Sanina Valentina Yu., Ph.D. in Chemistry, Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8-499-1905851; e-mail: info@gamaleya.org.

Responsible for correspondence with the editorial board: Kozhevnikova Tatyana N., Ph.D. in Immunology, Gamaleya Scientific Research Institute of Epidemiology and Microbiology; 18, Gamaleya st., Moscow, 123098; phone: 8499-190-58-51; e-mail: tatiana@micro-plus.ru.