Hematologic indices’ modification of animals after Escherichia Coli inactivated toxines injection

UDC 619:579.842.11-612.112.7

Terekhov V.I., Tishchenko A.S.

Summary. Escherichiosis of calfs and pigs is still wide-spread infectious pathology on farms in many parts of the world including Russia, despite performing vaccinal prevention of this disease. This phenomenon testifies imperfection to the used means of immunization which reason disharmony of antigenic structure of the vaccines to etiological and pathogenetic factors causing is development of escherichiosis. Having said the above designated, the actually question is combined of use enterotoxins E. coli as complex vaccinal preparation (anatoxin), however acquires relevance as they will influence an animal organism after introduction and what will have properties, it is unknown that demands carrying out special researches. In this regard the work objective was studying inactivated of mix influence enterotoxins on a picture of animals blood. Researchers have discovered that after intake anatoxin of rats primary reaction of immune system was expressed as increase in quantitative presence of physiologically mature neutrophils then observed increase in quantity of immune competent cell - lymphocytes. The dose of the entered anatoxin also mattered, than it was higher, especially expressed were the changes in a blood picture including which are shown the increased presence in the blood course of eosinophils. The inactivated enterotoxins of E. coli didn't possess toxic and cytopathological action at their intake in macroorganism, at the same time they have kept the antigene and immunostimulating properties that allow to consider as the applicant for complex vaccine preparations.

Keywords: escherichiosis, exotoxins, enterotoxins, Escherichia coli, anatoxin, blood, neutrophilic granulocytes, lymphocytes, white rats.

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Author affiliation:

Tishchenko Aleksandr S., Ph.D. in Veterinary Medicine, senior lecturer of the Department of Microbiology, Virology and Epizootology of the faculty of Veterinary Medicine of the Kuban State Agrarian University named after I.T Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-928-4692399; e-mail: mephisto83@inbox.ru.

Responsible for correspondence with the editorial board: Terekhov Vladimir I., D.Sc. in Biology, professor, Pashkovskiy Agricultural College; 220, E. Bershanskoy st., Krasnodar, 350910; phone: 8-988-4742115; e-mail: vterekhov@list.ru.