New aspects of quaternary ammonium compounds influence on gastrointestinal tract of chickens

УДК 576.89
DOI 10/33861/2071-8020-2025-3-29-32

Original Empirical Research

Klimenko A.I., Zubenko A.A., Fetisov L.N., Svyatogorova A.E., Chekrysheva V.V., Yarovaya N.A., Gritsay A.Yu.

Abstract. The objective of this study is to create alternative means of protecting and stimulating the development of animals and birds in early life. The use of cationic surfactants is one of the ways to solve this problem. Quaternary ammonium compounds (QAC) are a group of substances with pronounced antibacterial properties and the ability to act on a wide range of microorganisms. These compounds are actively used as disinfectants and biocides in medicine and veterinary medicine. The scientific literature of both domestic and foreign origin emphasizes the need to develop new QAC and expand their fields of application. Synthetic fatty acids, fatty alcohols, various oils and fatty amines are used as initial components for their synthesis. The present study presents the results of studying the effect of myristic acid 3-dimethylaminopropylamide (surfactant 726) on young meat breed chickens. It was found that the average weight of the glandular stomach in chickens of the experimental group who received 0.01% aqueous solution of surfactant 726 for 14 days was 5% more than in chickens of the control group; the average weight of the muscular stomach was 7% more than in the control group; the average weight of the intestine with contents in chickens of the experimental group It was 10% higher than the same indicators of the control group; the average liver weight was 6% higher in the chickens of the experimental group. It should be noted that differences in the mass of glandular and muscular stomachs, as well as liver, are statistically unreliable, while differences in the mass of intestines of experimental and control chickens are highly significant (p>0.999). The studied morphometric parameters of organs in chickens of the experimental group indicate a tendency to increase body weight and internal organs of chickens. The effect of growth stimulation is observed due to the use of surfactant 726, a quaternary ammonium compound.

Keywords: surfactants, quaternary ammonium compounds (QAC), myristic acid amide, morphometric parameters of chickens (live weight, hydrogen index of stomach and intestinal contents), determination of the residual ammount of surfactants 726.

Author affiliation:

Klimenko Aleksandr I., Academician of the Russian Academy of Sciences, D.Sc. in Agriculture, Professor, Director of the Federal Rostov Agrarian Scientific Center; 1, Institutskaya st., Rassvet vllg., Aksai district, Rostov region, 346735; e-mail: dzni@mail.ru.

Zubenko Aleksandr A., D.Sc. in Biology, Chief Scientific Researcher of the creative team for the chemical synthesis of new medicinal compounds of the North Caucasus Zonal Scientific Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-928-6049743; e-mail: alexsandrzubenko@yandex.ru.

Fetisov Leonid N., Ph.D. in Veterinary Medicine, Leading Scientific Researcher of the creative team on the chemical synthesis of new medicinal compounds of the North Caucasus Zonal Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-908-1978224; e-mail: fetisoff.leonid2018@yandex.ru.

Chekrysheva Viktoria V., D.Sc. in Veterinary Medicine, Docent, Director of the North Caucasus Zonal Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-918-5943886; e-mail: veterinar1987@mail.ru.

Yarovaya Nataliya A., laboratory researcher of the creative team for the chemical synthesis of new medicinal compounds of the North Caucasus Zonal Scientific Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-999-2340481; e-mail: tkhim.sintez@yandex.ru.

Gritsay Anna Yu., Junior Scientific Researcher of the creative team for the study of infectious pathology of animals of the North Caucasus Zonal Research Veterinary Institute -branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-908-5102689; e-mail: tkhim.sintez@yandex.ru.

Responsible for correspondence with the editorial board: Svyatogorova Aleksandra E., Ph.D. in Agriculture, Leading Scientific Researcher of the creative team for the chemical synthesis of new medicinal compounds, Academic Secretary of the North Caucasus Zonal Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; 0, Rostovskoe hgw., Novocherkassk, Rostov region, 346421; phone: 8-988-9525755; e-mail: sviatogorova.a@yandex.ru.

Author’s Contribution:

Klimenko A.I.: conceptualization, data curation, methodology, project administration, resources, supervision, writing - review & editing.

Zubenko A.A.: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, supervision, validation, visualization, writing - review & editing.

Fetisov L.N.: formal analysis, investigation, validation, visualization, writing -original draft preparation.

Svyatogorova A.E.: formal analysis, investigation, validation, visualization, writing -original draft preparation.

Chekrysheva V.V.: conceptualization, data curation, methodology, project administration, resources, supervision, visualization, writing - review & editing.

Yarovaya N.A.: investigation, validation, visualization, writing - original draft preparation.

Gritsay A.Yu.: investigation, validation, visualization writing - original draft preparation.

Conflict of Interest Statement: the authors declare no conflict of interest.