Preventive efficacy of the new agent clinocil in mycotoxicosis and gastrointestinal tract diseases caused by opportunistic microflora in dairy cows

УДК 631.95:637.5
DOI 10.33861/2071-8020-2025-3-8-11

Original Empirical Research

Miroshnichenko P.V., Danilchenko O.B.

Abstract. The study is devoted to a topical issue in animal husbandry - the impact of mycotoxins on the health and productivity of dairy cows. Every year, feed contamination with mycotoxins leads to significant economic losses due to decreased productivity and increased mortality of animals. In modern animal husbandry practice, it has become mandatory to include drugs and additives with antitoxic properties in the diet of animals. However, effective means of preventing mycotoxicosis are not enough, so one of the priority tasks in this area at present is the search and development of preventive regimens that include pharmacological agents aimed at restoring impaired functions and detoxifying the body of animals. Thus, we set a goal - to study the preventive effectiveness of a new agent for mycotoxicosis and gastrointestinal diseases caused by opportunistic microflora in dairy cows.

Materials and methods. The study was conducted at the Krasnodar Research Veterinary Institute, a separate structural division of the Federal State Budgetary Scientific Institution Krasnodar Scientific Center for Veterinary Medicine, and livestock farms in Krasnodar Region. The degree of contamination of livestock feed with mold fungi and mycotoxins used in farms in Krasnodar Region was monitored. The ability of the test agent to adsorb mycotoxins and affect opportunistic microflora contained in the feed of livestock farms where the experiments were conducted was studied in vitro. To study the prophylactic efficacy of the new agent in animal mycotoxicosis, studies were conducted on lactating cows.

Results. It was determined the content of mycotoxins in the studied feed. It was established in vitro the index of adsorbing capacity of Klinocil to T-2 toxin and zearalenone mycotoxin. It was studied the bactericidal ability of Klinocil. The effect of a new agent on the quantity and quality of milk obtained from lactating cows participating in the experiment was studied. The effect of the agent Klinocil on the biochemical parameters of the blood of lactating cows was studied and described. It was found that the hematological parameters of the animals of the experimental groups were within the physiological norms, which indicates the prophylactic effectiveness of the studied agent Klinocil. Discussion and conclusion. The empirically obtained results indicate that the agent Klinocil has adsorbing and bactericidal properties, which allows us to recommend its use for the prevention of mycotoxicosis in lactating cows. Further research in this area will allow us to study the therapeutic properties of the new agent.

Keywords: T-2 toxin, zearalenone, lactating cows, feed, intoxication, adsorption index, prevention of mycotoxicosis, opportunistic microflora.

Author affiliation:

Miroshnichenko Petr V., PhD., in Veterinary Medicine, leading scientific researcher, head of the department of epizootology, mycology and veterinary sanitary expertise of the Krasnodar Research Centre for Zootechnics and Veterinary Medicine; 1, 1 Line st., Krasnodar, 350004, phone: 8-918-4470155; e-mail: mpetrvas@mail.ru.

Responsible for correspondence with the editorial board: Danilchenko Olesya B., Ph.D. in Biology, senior scientific researcher of department of epizootology, mycology and veterinary sanitary expertise of the Krasnodar Research Centre for Zootechnics and Veterinary Medicine; 1, 1 Line st., Krasnodar, 350004, phone: 8-918-4521300; e-mail: danilchenkolesya@gmail.com.

Authors’ Contribution:

Miroshnichenko P.V.: conceptualization, investigation, writing - editing.

Danilchenko O.B.: investigation, visualization, validation, writing -original draft preparation.

Conflict of Interest Statement: the authors declare no conflict of interest.