Level of middle molecular mass peptides screening in system analysis of the efficiency of the use of drugs in the therapy of hepatopathies in cows

УДК 619:616.36 / 619:615.4
DOI 10.33861/2071-8020-2023-3-24-27

Abramov A. A., Kuzminova E. V., Semenenko M. P., Semenenko K. A, Koschaev A. G.

Summary. The article presents the results of studies to assess the applicability of MMM as a diagnostic criterion and a marker of the effectiveness of therapy for liver dystrophy in cows. The studies were carried out on 16 dairy cows with a confirmed diagnosis of «toxic liver dystrophy». All sick cows underwent detoxification therapy. Then they were divided into two groups. In the first group (experimental) an injectable hepatoprotector filokvertin was used, the second group (control) received only symptomatic treatment. Conducted pharmacotherapy showed the restoration of the liver parenchyma in 75% of cows, while in the control normalization of liver function occurred in 25% of the group. The results of studying the level of medium mass molecules (MCM254) in the blood of animals showed that this method is applicable as a tool for diagnosing the condition of the liver. It has been determined that MCM254 values can be an additional marker of biochemical control of ongoing pharmacotherapy, since their level was associated with the results of a clinical examination, biochemical tests, and ultrasound diagnostics of the state of the liver of animals.

Keywords: cows, hepatobiliary system, toxic liver dystrophy, blood, biochemical parameters, medium mass molecules, hepatoprotectors, therapy.

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Author affiliation:

Kuzminova Elena V., D.Sc. in Veterinary Medicine, docent, chief scientific researcher of the Department of Pharmacology of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine: 1, 1-ya Liniya st., Krasnodar, 350004: phone: 8-918-4198369: e-mail: niva1430@mail.ru.

Semenenko Marina P., D.Sc. in Veterinary Medicine, docent, Head of the Department of Pharmacology of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine: 1, 1-ya Liniya st., Krasnodar, 350004: phone: 8-918-4612663: e-mail: sever291@mail.ru.

Semenenko Ksenia Andreevna, PhD in Economics, senior scientific researcher of the Pharmacology Department of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; tel.: 8-918-4442242; e-mail: ksenia.semenenko@gmail.com

Koshchaev Andrey G., D.Sc. in Biology, professor, Academician of the Russian Academy of Sciences, Vice-Rector for scientific work of the Kuban State Agrarian University named after I.T. Trubilin: 13, Kalinina st., Krasnodar, 350044: phone: 8-861-2214637: е-mail: koshhaev.a@kubsau.ru.

Responsible for correspondence with the editorship: Abramov Andrey A., Ph.D. in Veterinary Medicine, senior scientific researcher of the Department of Pharmacology of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; phone: 8-902-4061527; e-mail: abramov1527@mail.ru.