To issue of treatment of animals with open mechanical damages

UDC 619:616-089

Okolelova A.I., Rodin I.A., Kuzminova E.V., Tarasov A.V.

Summary. Into the area of surgical pathology fall 40% of all noncontagious diseases. Hereby, significant losses of livestock are caused by wound injuries. The processes of tissue repair in wound injuries are often complicated by the sowing of wounds by pathogenic and conditionally pathogenic microflora. This makes the search for a combined effective drug for the treatment of infected wounds one of the urgent problems of veterinary medicine. For treating of wounds is used different etiology of the pharmacological preparations, which contain wide-stiched acrylic polymers, they form by putting on the skin the finest smooth films, have prolonged effect, are effective antiseptics, are distributed well on the mucos as and on the skin surface, have a cooling effect, are non-toxic and non-irritating, and are well removed with water. For the determination of the effectiveness of the proposed preparation, three groups with 15 animals in each group were selected - the control group and two experimental groups (calves at the age of six months). The animals of the groups were selected according to the principles of analogy. In each group the infected wounds were reproduced, then the medication was started. All animals were injured in the crupper region, using a stencil. The length of the wounds was 7 cm, the width 3 cm and the depth 3 cm. The animals in the control group were treated only through the cleanup of wounds. In other two groups the following treatment was conducted: first the cleanup of wounds, then putting on the ointments (in the first of two experimental groups for the treatment was used the tested ointment, into the second group they used the ointment Levomekol). The process of tissue reparation in all groups was completed in the different time: in the first experimental group within 19-20 days, in the second experimental group within 21-22 days, while in the control group within 23-24 days. From the obtained results of the conducted experiment follows, that the usage of hydrophilic ointment Gentadiovet during the treatment of the infected musculocutaneous wounds is more effective than Levomekol.

Keywords: wound injuries, pharmacological agents, ointment, liniments, antimicrobial action, antiseptic effect, side effects, reconstitue acrylic polymers , Gentadiovet, swelling, inflammation, granulation.

References.

1. Lutsevich O.E., Tamrazova O.B., Shikunova A.Yu. et. al. Sovremennyy vzglyad na patofiziologiyu i lecheniye gnoynykh ran [Modern view of pathophysiology and therapy of purulent wounds]. - Moscow, 2011 (5). - pp. 72-77.

2. Okolelova A.I., Rodin I.A., Kuzminova E.V. et. al. Primeneniye preparata "Gentadiovet" pri otkrytykh mekhanicheskikh povrezhdeniyakh u korov [Use of the preparation of Gentadiovet in open mechanical damage in cows]. - Veterinariya Kubani. - Krasnodar, 2015 (5). - pp. 13-15.

3. Timofeyev S.V., Paninskiy S.M., Kartushina I.A. Razyedineniye i soyedineniye tkaney kak elementy khirurgicheskoy operatsii [Disconnection and connection of tissues as elements of surgical operation]. - Moscow, 2005. - 65 p.

4. Chadayev A.P., Klimiashvili A.D. Sovremennyye metodiki mestnogo medikamentoznogo lecheniya infitsirovannykh ran [Modern methods of local medical therapy of infected wounds]. - Moscow, 2003 (1). - pp. 43-56.

5. Shekhter A.B., Berchenko T.N., Nikolaev A.V. Granulyatsionnaya tkan: vospaleniye i regeneratsiya [Granulation tissue: inflammation and regeneration]. - Moscow, 1984 (46 (2)). - pp. 20-29.

6. Shikova Yu.V. Biofarmatsevticheskoye obosnovaniye sostavov i razrabotka tekhnologii proizvodstva myagkikh lekarstvennykh form [Biopharmaceutical study of compositions and technology of production of soft medicinal forms]. - Ufa, 2005. - 368 p.

7-10. Vide supra.

Author affiliation:

Rodin Igor A., Professor, D.Sc. in Veterinary Medicine, Professor of the department of anatomy, veterinary obstetrics and surgery of the Kuban State Agrarian University named after I.T Trubilin; 13, Kalinina t., Krasnodar, 350044; phone: 8-861-2215784.

Kuzminova Elena V., D.Sc. in Veterinary Medicine, leading researcher of the laboratory of pharmacology of the Krasnodar Scientific-Research Veterinary Institute; 1, 1-ya Liniya, Krasnodar, 350004; phone: 8-861-2216220; e-mail: niva1430@mail.ru.

Tarasov Aleksandr V., post-graduate student of the laboratory of pharmacology of the Krasnodar Scientific-Research Veterinary Institute; 1, 1-ya Liniya, Krasnodar, 350004; phone: 8-861-2216220; e-mail: dima-32v@mail.ru.

Responsible for correspondence with the editorial board: Okolelova Anastasiya I., Ph.D. in Veterinary Medicine, assistant of the department of anatomy, veterinary obstetrics and surgery of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina t., Krasnodar, 350044; phone: 8-861-2215784; e-mail: milchbrotchen@mail.ru.