Impact of inactivated virus vaccine administration on cattle immune response

Mishchenko A.V., Dumova V.V., Mishchenko V.A, Kononov A.V., Chernykh O.Yu.

Summary

Sorbated and emulsion vaccines, that were different in methods of administration (subcutaneous and intramuscular), were used for prevention of cattle diseases. No reactogenicity was observed during clinical examination of vaccinated down-calving cows and youngsters. The analysis of results of laboratory investigations revealed no difference in titres of coronavirus antibodies in blood sera from intramuscularly or subcutaneously vaccinated down-calving cows and their newborn calves, that were promptly fed by colostrum.

The level of virus specific antibodies to infectious rhinotracheitis virus and coronavirus in blood sera from immunized youngsters as well as the duration of postvaccinal humoral immunity did not depend on a method of vaccine administration. Subcutaneous or intramuscular administration of antiviral inactivated vaccines exerts no significant influence on a level of postvaccinal antibodies.

Key words: large horned cattle, inactivated vaccine, sorbated vaccine, emulsion vaccine, antibodies, coronavirus, infectious rhinotracheitis virus, indirect hemagglutination test, down-calving cows, youngsters.

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Author affiliation

Mishchenko Aleksey V., Ph.D. in Veterinary Medicine, senior researcher of the laboratory of diagnostics of farm animals’ diseases of the Federal State Establishment "Federal Centre of Animal Health" (FSE "All-Russian Research Institute of Animal Health"); mcrd. Yuryevets, Vladimir, Russia, 600901; phone: (4922) 26-17-65 23-14; e-mail: mishenko@arriah.ru.

Mishchenko Vladimir A., D.Sc. in Veterinary Medicine, professor, chief expert for bovine diseases of Federal State Establishment "Federal Centre of Animal Health" (FSE "All-Russian Research Institute of Animal Health"); mcrd. Yuryevets, Vladimir, Russia, 600901; phone: (4922) 26-17-65 20-83; e-mail: mishenko@arriah.ru.

Chernykh Oleg Yu., D.Sc. in Veterinary Medicine, director of the Kropotkin territorial veterinary laboratory; 303, Krasnoarmeyskaya st., Kropotkin, 352380; phone: 8 (86138) 6-23-14; e-mail: gukkvl50@kubanvet.ru.

Kononov Aleksander V., Ph.D. in Veterinary Medicine, senior researcher of the laboratory of prevention of pigs’ and cattle diseases of the Federal State Establishment "Federal Centre of Animal Health" (FSE "All-Russian Research Institute of Animal Health"); mcrd. Yuryevets, Vladimir, Russia, 600901; phone: (4922) 26-17-65 20-34; e-mail: kononov@arriah.ru.

Responsible for correspondence with the editorial board: Dumova Viktoriya V., Ph.D. in Biology; senior scientific researcher of the laboratory for bovine diseases of the Federal State Establishment "Federal Centre of Animal Health" (FSE "All-Russian Research Institute of Animal Health"); mcrd. Yuryevets, Vladimir, Russia, 600901; phone: (4922) 26-17-65 20-85; e-mail: dumova@arriah.ru.