Nfluence of revinorm on oxidative stress and endogenous intoxication indicators in the blood of laboratory animals during acute hyperthermia

УДК 619:615.4 / 615.076.9
DOI 10.33861/2071-8020-2025-2-23-25

Original Empirical Research

Kuzminova E.V., Semenenko M.P., Abramov A.A., Zheleznyakova K.A.

Abstract. Due to the global warming caused by technogenic influences, the planet is experiencing an abnormal increase in average temperature, which negatively affects human and animal health. Thermal overheating of the body can lead to the development of oxidative stress and an increase in the level of endogenous intoxication, which are pathogenetic factors in the occurrence of various diseases. The aim of the work was to study the influence of the drug revinorm on the indices of oxidative stress and endogenous intoxication in the blood of laboratory rats during experimental acute hyperthermia. When modeling acute hyperthermia, 4 groups of nonlinear rats were formed with 10 individuals in each. Groups 1 and 2 were experimental (during thermal exposure they received the drug revinorm in different doses), group 3 served as a control (did not receive treatment), and group 4 consisted of intact healthy rats kept in vivarium conditions. The results of the study showed that revinorm exhibits pronounced pharmacological activity in acute thermal hyperthermia of laboratory rats, which is manifested by an increase in the survival rate of rodents, a decrease in the severity of clinical signs of hyperthermia, blood levels of lipid peroxidation indicators and endogenous intoxication. An effective dose of revinorm was determined on laboratory animals, amounting to 0.6 g / kg of body weight, which serves as a justification for the stage of clinical trials of the drug on productive animals under heat stress.

Keywords: drug revinorm, laboratory rats, acute hyperthermia, blood, oxidative stress, endogenous intoxication.

Author affiliation:

Semenenko Marina P., D.Sc. in Veterinary Medicine, Docent, Head of the Pharmacology Department of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; phone: 8-918-4612663; e-mail: sever291@mail.ru.

Abramov Andrey A., Ph.D. in Veterinary Medicine, Senior Scientific Researcher of the Pharmacology Department of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; phone: 8-902-4061527; е-mail: abramov1527@mail.ru.

Zheleznyakova Ksenia A., Ph.D. in Economics, Senior Scientific Researcher of the Pharmacology Department of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; phone: 8-918-4442242; е-mail: ksenia.andreevna0708@gmail.ru.

Responsible for correspondence with the editorial board: Kuzminova Elena V., D.Sc. in Veterinary Medicine, Docent, Chief Scientific Researcher of the Pharmacology Department of the Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine; 1, 1-ya Liniya st., Krasnodar, 350004; phone: 8-918-4198369; е-mail: niva1430@mail.ru.

Authors’ Contribution:

Kuzminova E.V.: conceptualization, data curation, writing - editing.

Semenenko M.P.: resources, supervision, project administration.

Abramov A.A.: investigation, visualization, writing - original draft preparation.

Zheleznyakova K.A.: investigation, formal analysis, validation, visualization.

Conflict of Interest Statement: the authors declare no conflict of interest.