Promising methods of treating skin wounds in veterinary medicine

DOI 10.33861/2071-8020-2021-2-52-53

Nadezhdin D.V.

Summary. Skin as an organ with a clearly pronounced borderline, in particular, barrier-protective function has long been of interest to researchers. Skin lesions, especially long-term non-healing or chronic wounds, are a topical problem of veterinary medicine. Reparative regeneration is complex multistage, which is based on a complex of numerous biochemical, immunological and genetic mechanisms, considered in the regenerative process as homeostatic and regulatory. Despite the large number of drugs of natural and synthetic origin with reparative properties, interest in this problem remains high, since existing drugs are not all quite effective. Currently, in veterinary clinical medicine, the use of stem cells was a widespread and promising method of treating many pathologies, including those related to the skin. In recent years, subcutaneous fatty fiber has been used as an alternative source of stem and pro-genitor cells for regenerative medicine, the sampling procedure of which is characterized by much less invasiveness compared to bone marrow aspiration. The most promising material for cell therapy of skin wound defects is currently multipotent mesenechemical stromal cells and stromal-vascular fraction, capable by paracrine production of cytokines, chemoattractants and growth factors to stimulate the regeneration process. Being universal regulators of regenerative process, MMSCs and participate in wound healing at almost all its stages: change process of inflammation course, stimulate proliferation of epitelia and fibroblasts, promote angiogenesis. However, a comprehensive morphological assessment of the skin repair process has not been found in the available literature.

Keywords: skin, tissue, wound, regenerate, scar, remodeling, regeneration, reparative regeneration, autologous cellular products, stromal-vascular fraction, multipotent mesenchymal stromal cells.

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Author affiliation: Nadezhdin Dmitriy V., postgraduate student of the department of animal anatomy and histology named after professor A.F. Klimov of the Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K.I. Skryabin; 8 apt., 7, Dubki vllg., Ramensky district, Moscow region, 140163; phone: 8-901-3609867; e-mail: nadaki@mail.ru - responsible for correspondence with the editorial board.