Enteroprotective properties of myristic acid amide study in broiler chickens

DOI 10.33861/2071-8020-2020-21-23

Drobin Yu.D., Zubenko A.A., Bokun E.A., Bodryakov A.N., Chernykh O.Yu., Lysenko A.A.

Summary. As a result of an experimental study on broiler chickens, the enteroprotective effect of myristic acid amide in mycotoxicosis in chickens was established. An experiment was conducted to study the effectiveness of the use of new cationic surfactants in the form of aqueous solutions of fatty acid amides in case of mycotoxicosis on young poultry. During the study, the content of mycotoxins in the feed was established, the effect of deoxynivalenol and citrinin mycotoxins on the broiler chickens was determined, the enteroprotective effect of a 0.01% aqueous solution of myristic acid amide was studied when feeding chickens contaminated with mycotoxins DON and citrinin in quantities exceeding the maximum allowable level. In chickens of the 1st experimental group, which from the first day of life were given food contaminated with mycotoxin DON in an amount exceeding the MDL by 3 times, signs of diarrhea with an admixture of blood were observed. The incidence rate was 80%, and the mortality rate was 33.3%. Chickens were significantly stunted. Introduction from day 8 of a 0.01% solution of myristic acid amide practically did not give a positive effect. Where a 0.01% solution of myristic acid amide was given from the 1st day of the experiment, the incidence was 30.0%, no deaths were observed. The average live weight of the chicken in this group is only 66 g less than the control group. In the 3rd group, where the chickens received citrinin-contaminated food (with a 25-fold excess of the MDL), the incidence was 40% and the mortality rate was 10%. The average live weight of 1 chicken on the 35th day of life was 226 g less compared to the control. The protective effect of a 0.01% aqueous solution of myristic acid amide in experimental citrinin toxicosis was less pronounced. Nevertheless, in this case, the protective effect was established, since according to the literature 25 times the maximum permissible level of feed contamination with citrinin is fatal for all young chickens.

Keywords: citrinin, mycotoxicoses, chickens, intestines, myristic acid amide, surfactants, weight gain, xenobiotics, antioxidant protection, fatty acid amides, deoxynivalenol.

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Author affiliation:

Drobin Yury D., Ph.D. in Veterinary Medicine, Director of the North Caucasian Zonal Scientific-Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; Rostov hgw., Novocherkassk, Rostov region, 346421; e-mail: skznivi@novoch.ru.

Zubenko Aleksandr A., D.Sc. in Biology, chief scientific researcher of the North Caucasian Zonal Scientific-Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; Rostov hgw., Novocherkassk, Rostov region, 346421; e-mail: alexsandrzubenko@yandex.ru.

Bokun Evgeniya A., senior scientific researcher of the North Caucasian Zonal Scientific-Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; Rostov hgw., Novocherkassk, Rostov region, 346421; e-mail: shlypnikova61@gmail.ru.

Bodryakov Anatoliy N., Ph.D. in Veterinary Medicine, senior scientific researcher of the North Caucasian Zonal Scientific-Research Veterinary Institute - branch of the Federal Rostov Agrarian Scientific Center; Rostov hgw., Novocherkassk, Rostov region, 346421; e-mail: abodryakov@yandex.ru.

Chernykh Oleg Yu., D.Sc. in Veterinary Medicine, director of the Kropotkin regional veterinary laboratory; 303, Krasnoarmeyskaya st., Kropotkin, 352380; phone: 8-918-4956659; e-mail: gukkvl50@kubanvet.ru.

Responsible for correspondence with the editorial board: Lysenko Aleksandr A., D.Sc. in Veterinary Medicine, professor, professor of the department of therapy and pharmacology of the Kuban State Agrarian University named after I.T. Trubilin; 7, 29, Rozhdestvenskaya emb., Krasnodar, 350089; phone: 8-9615075415; e-mail: vet.kubgau@mail.ru.