Mebisel and Emicidine influence on system of antioxidant defense in cows during postpartum period

UDC: 619-615.038-615.036-618.6

Kireev I.V., Orobets V.A, Belyaev V.A., Denisenko T.S., Petrichenko A.A.

Summary. Multi-system of antioxidant defense plays the leading role in the regulation of free radical oxidation of lipids in the adaptation, especially when the stressful situation involves fundamental changes in the oxygen regime, which determines the intensity of these processes. Results of tests of a new organoselenium preparation Mebisel in comparison with the preparation Emicidin on cows on the last month of pregnancy and during the postpartum period are presented in the article. The experiment was conducted on the basis of Novomarevsky farm of Shpakovsky district of Stavropol region. Three groups of cows in the last month of pregnancy (ten animals in each group) were used in the tests. Cows in the first group were injected with the preparation Emicidin intramuscularly once a day for five days at a dose of 40 ml per animal a month before the expected calving. Parallel to this, the cows in the second group were injected a single intramuscular dose of the preparation Mebisel (8 ml per cow). No preparation was used in the third group – animals were used as controls. Second injection of the preparation in the first and second groups was made after calving. During the experiment it was found that the use of Mebisel has a positive results on the characteristics of the antioxidant defense of the organism.

Keywords: cows, adaptation, reproductive system, postpartum period, antioxidant defense, resistance, emicidin, mebisel, selen, vitamin E.

References:

1. Zhavoronok T.V., Stepovaia E.A., Riazantseva N.V. Narushenie okislitelnogo metabolizma pri ostrykh vospalitelnykh zabolevaniiakh [Violation of oxidative metabolism in acute infl ammatory diseases]. – 2006 (12). – pp. 10-14.

2. Kireev I.V. Farmako-toksikologicheskie svoistva ekstraselena i ego primenenie v veterinarii [Pharmaco-toxicological properties ekstraselena and its application in veterinary medicine]. – KubSAU. – Krasnodar, 2009. – 22 p.

3. Miroshnikova A.I., Kireev I.V., Orobets V.A. Lechenie klinicheskikh form mastita u korov v poslerodovoi period [Therapy of clinical forms of mastitis in cows in postpartum period]. – Trudy KubGAU. – Krasnodar, 2013 (43). – pp. 203-205.

4. Orobets V.A., Beliaev V.A., Kireev I.V. Vliianie mebisela na produktivnost molodniaka krupnogo rogatogo skota [Infl uence of mebisel on productivity of young growth of large horned cattle]. – Veterinarnaia praktika. – Saint-Petersburg, 2008 (2). – pp. 36-38.

5. Papazian T.T., Fisinin V.I., Surai P.F. Vzaimodeistvie mezhdu vitaminom E i selenom: novyi vzgliad na staruiu problemu [Interaction between vitamin E and selenium: new look at an old problem]. – 2009 (1). – pp. 37-39.

6. Retskii M.I., Buzlama V.S., Kaverin N.N., Zolotarev A.I., Bykova S.V. Perekisnoe okislenie lipidov i sistema antioksidantnoi zashhity v period rannei postnatalnoi adaptatsii teliat [Lipid peroxidation and antioxidant defense system in early postnatal adaptation of calves]. – Sel’skokhozyaistvennaya biologiya. – Moscow, 2004 (2). – pp. 56-60.

7. Retskii M.I., Samotin A.M., Bliznetsov G.N. Antioksidantnyi status pri zhirovoi distrofi i pecheni u bychkov [Antioxidant status with fatty liver disease in bulls]. – Sel’skohozyaistvennaya biologiya. – Moscow, 2008 (4). – pp. 106-109.

8. Retskii M.I., Shabunin S.V., Bliznetsova G.N. Mobilizatsiia svobodnoradikalnykh protsessov v neitrofi lakh krovi pri raznykh formakh bronkhopnevmonii u teliat [Mobilization of free radical processes in the blood neutrophils in various forms of pneumonia in calves]. – Sel’skohozyaistvennaya biologiya. – Moscow, 2010 (2). – pp. 100-102.

9. Sevostianova O.I. Novyi razrabotannyi preparat "Ekstraselen-viteel" – vliianie na produktivnost tsipliat-broilerov [Newly developed preparation Extraselen-Viteel – influence on the productivity of broiler chickens]. – Saint Petersburg, 2014. – pp. 233-235.

10. Tiunov L.A. Mehanizmy estestvennoi detoksikatsii i antioksidantnoi zashchity [Mechanisms of natural detoxifi cation and antioxidant protection]. – Vestnik RAMN. – Moscow, 1995 (3). – pp. 9-12.

Author affiliation:

Kireev Ivan V., Ph.D. in Biology, docent of the department of pharmacology and therapy of the Stavropol State Agrarian University; 12, Zootechnicheskii lane, Stavropol, Stavropol region, 355017; phone: 8(962)441-29-37; e-mail: kireev-iv@mail.ru.

Belyaev Valeriy A., D.Sc. in Veterinary Medicine, professor, professor of the department of pharmacology and therapy of the Stavropol State Agrarian University; 12, Zootechnicheskii lane, Stavropol, Stavropol region, 355017; phone: 8(928)313-73-06; e-mail: valstavvet@yandex.ru.

Denisenko Tatiana S., post-graduate student of the department of pharmacology and therapy of the Stavropol State Agrarian University; 12, Zootechnicheskii lane, Stavropol, Stavropol region, 355017; phone: 8(963)381-31-83; e-mail: chernova_ts@mail.ru.

Petrichenko Anastasia A., student of the faculty of Veterinary Medicine of the Stavropol State Agrarian University; 12, Zootechnicheskii lane, Stavropol, Stavropol region, 355017; phone: 8(968)268-31-08; e-mail: pink2014@yandex.ru.

Responsible for correspondence with the editorial board: Orobets Vladimir A., D. Sc. in Veterinary Medicine, Professor, Head of of the department of pharmacology and therapy of the Stavropol State Agrarian University; 12, Zootechnicheskii lane, Stavropol, Stavropol region, 355017; phone: 8(928)327-60-16; e-mail: orobets@yandex.ru.