Kidney haemodynamics and correction of its disturbance In dogs at dirofilariasis

Kolody I.V., Ermakov A.M., Boyko V.P.

Summary

It is important to study the state of renal haemodynamics and development of effective methods of correction of violations especially at the early stages of dirofilariasis in dogs. Renal blood flow of 20 dogs with dirofilariasis was investigated by means of ultrasonic dopplerography. Increase of absolute indices of blood flow (Pourcelot resistance index, Gosling pulsatility index) was revealed. Absolute speed indices took almost normal values in one month in the group of dogs that received combined therapy by antithrombotic, antiparasitic drugs and ACE inhibitors. Thus, study of renal blood flow in dogs at dirofilariasis allows to reveal disturbance, optimize therapeutical tactics and prevent the development of fatal complications.

Key words: dirofilariasis, transmissible diseases, ultrasonography, dopplerography, renal blood flow, angiotensin-converting enzyme inhibitor.

References

1. Pavlova Ya.Ya., Sabirov I.S. Vozmozhnosti ispolzovaniya ingibitora angiotenzin-prevrashchayushchego fermenta enalaprila u bolnykh s gipoksicheskoy legochnoy gipertenziey [Possibility of use of angiotensin-converting enzyme inhibitor enalapril at patients at hypoxic pulmonary hypertension]. – 2003: 50-54.
2. Ratner M.Ya. Gomeostaticheskie pochechnye funktsii pri khronicheskikh diffuznykh nefropatiyakh [Homeostatic renal functions at chronic diffuse nephropathies]. – 1987: 25-30.
3. Kolody I.V., Sereda S.V., Ermakov A.M., Bardyukova T.V., Zueva N.M. Rol dvumernoy ekhokardiografii v diagnostike pravozheludochkovoy serdechnoy nedostatochnosti, vyzvannoy Dirofilaria immitis [Role of two-dimensional echocardiography in diagnosis of right heart failure caused by Dirofilaria immitis]. – 2009: 107-110.
4. Sheyman D.A. Patofiziologiya pochki [Pathophysiology of kidney]. – 1999: 206 p. – Translated from English.
5. Casey H.W., Splitter G.A. Membranous glomerulonephritis in dogs infected with Dirofilaria immitis // Vet Pathol. 1975;12(2):111-7.
6. Experimental Dirofilaria immitis-associated glomerulonephritis induced in part by in situ formation of immune complexes in the glomerular capillary wall / G.F. Grauer, C.A. Culham [et al.] // J Parasitol. 1989 Aug;75(4):585-93.
7. Kidney ultrastructural lesions in dogs experimentally infected with Dirofilaria immitis (Leidy, 1856) / E. C. Paes-de-Almeida [et al.] // Veterinary Parasitology. Vol. 113, Issue 2. 2003. P. 157-168.
8. Kramer L.H. Pathogenesis of Dirofilaria spp. infections. Second European Dirofilaria Days, Salamanca, Spain. 2009. P.116-123.
9. Structural and functional parameters of impaired right ventricular heart function caused by Dirofilaria immitis in dogs / Kolodyi I.V., Ermakov A.M., Kartashev V.V., Simon F. // 35th Congress of the World Small Animal Veterinary Association, Geneva. 2010. P.29.

Author affiliation

Ermakov Alexey M., D.Sc. in Biology, professor, North Caucasian Zonal Scientific-Research Veterinary Institute; 346421, Rostov highway, Novocherkassk, Rostov Region; phone: (8635)227105.

Boyko Vasily P., applicant of the North Caucasian Zonal Scientific-Research Veterinary Institute; 346421, Rostov highway, Novocherkassk, Rostov Region; phone: (8635)227105.

Responsible for correspondence with the editorial board: Kolody Irina V., Ph.D. in Biology, North Caucasian Zonal Scientific-Research Veterinary Institute; 346421, Rostov highway, Novocherkassk, Rostov Region; phone: (863)2926537; e-mail: kolody@li.ru.