Evaluation of the effect of mineral adaptogen on the morphohistochemistry of some internal organs during immunosuppression in animals in an experiment

УДК 636.028-573.38/576.08
DOI 10.33861/2071-8020-2023-1-29-34

Drozd M.N., Usevich V.M.

Summary: Modern technological conditions of keeping and exploitation of animals and poultry expose them to constant stress. This leads to a decrease in the body’s resistance, an increase in morbidity and mortality. In addition, the quantity and quality of the products obtained are reduced. Stress prevention helps to increase the body’s resistance. The search for effective means of preventing stress reactions of the body in animal husbandry and poultry farming is an urgent problem of practical veterinary medicine. Polymineral feed additives of natural and artificial origin may exhibit adaptogenic properties. The aim of the study is to evaluate the immuno- and organoprotective activity of a mineral adaptogen of domestic production in experimental conditions. Materials and methods. To confirm the effectiveness of the mineral adaptogen, histological, morphometric and histochemical studies of stress-dependent organs, organs directly in contact with the mineral adaptogen, organs of excretion of metabolic products and the body regulating homeostasis in the body were carried out. As a result of the conducted studies, the organoprotective function of the mineral adaptogen was revealed. The most sensitive organs to the action of adverse factors (liver, kidneys, adrenal glands) have been identified. Morphometrically determined the reliability of morphological changes in organs. During prophylactic feeding of mineral adaptogen in the studied organs (spleen, adrenal gland, kidneys, liver, stomach, small intestine), the revealed changes did not have total destruction, approaching the structure and metabolic processes in cells to the structure of these organs in intact animals. Scientific novelty. For the first time, a comparative morphohistochemical and morphometric assessment of some internal organs in animals under conditions of artificially induced immunosuppression was carried out, confirming the immune and organoprotective effect of a mineral adaptogen - a mineral feed additive of domestic production.

Keywords: stress, immunosuppression, adaptogen, homeostasis, histology, histochemistry, morphometry, laboratory animals, feed additive, stress prevention.

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Author affiliation:

Drozd Marya N., postgraduate student, assistant of the Department of Infectious and Non-infectious Pathology of the Ural State Agrarian University; 42, Karla Liebknekhta st., Ekaterinburg, 620075; phone: 8-904-5425823; e-mail: umn100@yandex.ru.

Responsible for correspondence with the editorial board: Usevich Vera M., Ph.D. in Veterinary Medicine, docent, docent of the Department of Infectious and Non-Infectious Pathology of the Ural State Agrarian University; 42, Karla Liebknekhta st., Ekaterinburg, 620075; phone: 8-904-5425225; e-mail: vus5@yandex.ru.