Double blind randomized controlled study in vivo of antitoxic effect of Gamavit and Gamavitforte against imydocarb dipropionate

Salichev A.V., Ozherelkov S.V., Izmesteva A.V., Videnina A.A., Kozhevnikova T.N., Sanin A.V.

Summary

Gamavit is a veterinary drug traditionally used as a detoxicant and hematopoietic stimulant during therapy of canine babesiose. Results of double blind randomized controlled study in vivo of antitoxic effect of Gamavit and its new form GamavitForte against imydocarb dipropionate commercially produced as PIRO-STOP are presented in the article. Authors found that both Gamavit and GamavitForte extend significant antitoxic effect that was more pronounced with GamavitForte. Comparing with Gamavit, the composition of the former is further strengthened with human recombinant interferon alpha, succinic acid and pyruvic acid. We conclude that GamavitForte may be used as effective detoxicant while treating canine babesiose.

Key words: Gamavit, GamavitForte, imydocarb, PIRO-STOP, babesiose of dogs.

References

1. Annikov V.V., Annikova L.V., Popova M.E. Kliniko-biokhimicheskoe obosnovanie effektivnosti primeneniya gamavitaforte pri babezioze sobak [Clinical and biochemical justification of the efficiency of Gamavit-Forte at babesiose of dogs]. – Moscow (2009): pp. 21-23. – Print. (in Russ.).
2. Belimenko V.V. Babezioz sobak v Orenburgskoy i Moskovskoy oblastyakh [Babesiose in Orenburg and Moscow areas]. – Moscow. – 2008. – Print. (in Russ.).
3. Zaytseva L.G., Bekhalo V.A., Vasilev I.K., Godunov R.S., Kireeva I.V., Kozhevnikova T.N., Nagurskaya E.V., Narovlyansky A.N., Ozherelkov S.V., Pronin A.V., Sanin A.V. Korrektsiya funkcionalnoy aktivnosti peritonealnykh makrofagov myshey Fosprenilom i Gamavitom pri vvedenii vysokikh doz α-toksina Staphylococcus aureus [Correction of functional activity of peritoneal macrophages of mice by Fosprenyl and Gamavit at injection of high doses of α-toxin of Staphylococcus aureus]. – Mikrobiologiya. – 2006. – pp. 51-57. – Print. (in Russ.).
4. Zverev A.A. Farmako-toksikologicheskaya kharakteristika i terapevticheskaya effektivnost imidokarba 5% pri babezioze sobak [Pharmacotoxicological characteristics and therapeutic efficiency of imydocarb 5% at babesiose of dogs]. – Moscow. – 2008. – Print. (in Russ.).
5. Leonard R.A. Vliyanie Gamavita, Fosprenila i Maksidina na ryad biokhimicheskikh pokazateley krovi sobak, bolnykh piroplazmozom [Influence of Gamavit, Fosprenyl and Maxidine at a number of biochemical indices of blood of dogs suffering from piroplasmose]. – Veterinarnaya klinika. – 2006. – pp. 2-5. – Print. (in Russ.).
6. Obryvin V.N., Zhorov G.A., Rubchenkov P.N. Vliyanie preparatov Gamavit i Gala-Vet na toksicheskiy immunodefitsit u belykh krys [Influence of Gamavit and GalaVet on toxic immune deficiency in white rats]. – Veterinarnaya patologiya. – 2008. – pp.119-125. – Print. (in Russ.).
7. Samoylova E.S., Derkho M.A. Iz opyta primeneniya antioksidantov v kompleksnoy skheme lecheniya babezioza [From the experience of application of antioxidants in complex system of treatment of babesiose]. – http://sobachnik.siteedit.ru/page14. – in Russ.
8. Sanin A.V., Pronin A.V., Narovlyansky A.N. Gamavitforte: ozhidaniya i realnost [Gamavit Forte: expectations and reality]. – Kazan (2011): pp.59-61. – Print. (in Russ.).
9. Sanin A.V. Gamavit – effektivnoe sredstvo pri ekstrakorpuskulyarnykh anemiyakh [Gamavit – effective mean at extracorpuscular anemia]. – Veterinarnaya klinika. – 2009. – pp. 16-19. – Print. (in Russ.).
10. Sanin A.V., Vasilev I.K., Godunov R.S., Ozherelkov S.V. Eksperimentalnoe obosnovanie primeneniya Gamavita pri degelmintizatsii zhivotnykh chetyrekhkhloristym uglerodom [Experimental justification of application of Gamavit for dehelminthization of animals with carbon tetrachloride]. – Kazan (2004): pp.27-30. – Print. (in Russ.).
11. Sanin A.V., Narovlyansky A.N., Ozherelkov S.V., Pronin A.V., Sanina V.Yu. Immunomodulyatory v veterinarnoy praktike: primenenie i protivorechiya [Immunomodulators in veterinary practice: application and contradictions]. – Veterinarnaya klinika. – 2008. – pp. 28-31. – Print. (in Russ.).
12. Sanin A.V., Vasilev I.K. Problema snizheniya toksichnosti antiprotozoynykh preparatov pri babezioze sobak [Problem of reducing the toxicity of antiprotozoal drugs at babesiose of dogs]. – 2007. – pp. 43-45. – Print. (in Russ.).
13. Sanin A.V., Zaytseva L.G., Kireeva I.V., Berezina L.K., Sanina V.Yu., Pronin A.V., Narovlyansky A.N. Gamavit – antidotnaya terapiya pri oksidativnom stresse [Gamavit – antidote therapy at oxidative stress]. – Veterinarny doctor. – 2008. – pp. 7-8. – Print. (in Russ.).
14. Seliverstov A.S. Imidosan – shag vpered v borbe s piroplazmozom [Imidosan – a step forward in the fight against piroplasmose]. – Veterinarnaya klinika. – 2009. – p. 13. – Print. (in Russ.).
15. Furman I.M., Fedorchenko O.A., Glamazdin I.G., Shelaputina I.A., Zinkina T.S., Bogautdinova T.V., Nikitin O.A., Vasilev I.K., Sanin A.V. Novy podkhod k lecheniyu piroplazmoza u sobak [New approach to the treatment of piroplasmose of dogs]. – Veterinar. – 2005. – pp. 24-25. – Print. (in Russ.).

Author affiliation

Salichev Anton V., post-graduate student, junior research assistant of the Chumakov Institute of Poliomyelitis and Viral Encephalitis (Moscow); phone: 498-540-93-16; salichev@inbox.ru.

Izmesteva Anna V., junior research assistant of the laboratory of cytokines of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology (Moscow).

Videnina Anna A., junior research assistant of the laboratory of cellular immunity of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology (Moscow); phone: 499-193-4355; e-mail: videnina-anna@rambler.ru.

Kozhevnikova Tatyana N., Ph.D. in Medicine, research associate of the laboratory of cellular immunity of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology (Moscow); phone: 499-193-4355; e-mail: tatiana@micro-plus.ru.

Sanin Aleksandr V., D.Sc. in Biology, professor, head of the laboratory of cellular immunity of the Gamaleya Scientific Research Institute of Epidemiology and Microbiology (Moscow); phone: 985-226-2897; e-mail: saninalex@inbox.ru.

Responsible for correspondence with the editorial board: Ozherelkov Sergey V., D.Sc. in Biology, laboratory manager of the Chumakov Institute of Poliomyelitis and Viral Encephalitis (Moscow); phone: 498-540-93-16; e-mail ozherelkov@yandex.ru.