ÓÄÊ: 619:616-022.7:615.33
DOI 10.33861/2071-8020-2025-4-40-43
Scoping Review
Mikhailov I. V., Pimenov N. V.
Abstract. The problem of antibiotic resistance in epizootic strains of Staphylococcus pseudintermedius in domestic animals is increasingly relevant in veterinary medicine, especially due to the rise in methicillin-resistant strains (MRSP). However, the prevalence of MRSP in Russia, mechanisms of resistance transmission, and potential alternative therapeutic approaches such as phage therapy have not been sufficiently studied. A systematic analysis of scientific publications from PubMed, Scopus, Web of Science, and eLibrary databases covering the period from 2005 to 2023 was conducted, focusing on MRSP prevalence, mechanisms of antibiotic resistance, and prospects of phage therapy in veterinary practice. Original articles, reviews, and dissertations were reviewed, with 18 most relevant sources selected. The analysis revealed that MRSP prevalence varies from 11% to 50% across different regions globally. The primary resistance mechanisms involve the mecA gene and mobile genetic elements, facilitating rapid horizontal transfer of resistance genes among strains. Successful examples of phage therapy in veterinary medicine, demonstrating its effectiveness against MRSP, especially in treating refractory infections such as purulent otitis in cats and dogs, have been reviewed. The growing multidrug resistance of MRSP complicates treatment and infection prevention, necessitating the development of new strategies and alternative therapeutic methods. Phage therapy is a promising direction; however, further research and clinical trials are required for its broad adoption in practice. Increasing awareness among veterinary professionals and pet owners about antibiotic resistance is crucial for effectively addressing this challenge.
Keywords: Staphylococcus pseudintermedius, antibiotic resistance, phage therapy, epizootic strains, veterinary medicine, genetic mobility, resistance, methicillin-resistant strains, skin diseases in animals, antimicrobial resistance.
Author affiliation:
Pimenov Nikolay V., D.Sc. in Biology, Head of the Department of Immunology and Biotechnology of the Moscow State Academy of Veterinary Medicine and Biotechnology - MVA named after K.I. Skryabin; 23, Akademika Skryabina st., Moscow, 109472; e-mail: pimenov-nikolai@yandex.ru.
Responsible for correspondence with the editorial board: Mikhailov Igor V., postgraduate student of the Department of Immunology and Biotechnology of the Moscow State Academy of Veterinary Medicine and Biotechnology -MVA named after K.I. Skryabin; 23, Akademika Skryabina st., Moscow, 109472; e-mail: vash.vet@mail.ru.
Authors’ Contribution:
Mikhailov I. V.: formal analysis, investigation, validation, visualization, writing - original draft preparation.
Pimenov N. V.: conceptualization, supervision, data curation, investigation, writing - review & editing.
Conflict of Interest Statement: the authors declare no conflict of interest.
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