ÓÄÊ 619:616-08:636.92
DOI 10.33861/2071-8020-2023-4-31-34
Petrova I. V., Zhilina K. V., Semikrasova A. N.
Summary. Authors studied morphological changes in the liver and intestines of rabbits with coccidiosis after various therapy regimens. Toltrex 2,5 chemical coccidiostatic was used as an anticoccidial drug, 1 ml of which contains toltrazuril - 25 mg as an active substance (Mucinol Extra) was used as a probiotic. For the experiment, 3 groups of rabbits with coccidiosis (10 heads each group) were formed, which were treated according to different schemes. The animals of the first group were given an anticoccidium drug according to the instructions, the second group was given an anticoccidium drug in combination with a probiotic, the third group was not given drugs. In 33 all groups of rabbits, coprological studies were carried out by the Fulleborn method to identify coccidia oocysts. According to the results of the studies, the extent and intensity of the effectiveness of treatment regimens was calculated. 30 days after the end of therapy, the rabbits were slaughtered for histological examination of the liver and intestines. As a result of the conducted studies, it was found that the treatment based on the complex use of Toltrex 2,5 anticoccidium drug in a dose of 1 ml of the drug per 1 liter of water for 48 hours and Mucinol Extra probiotic drug in a dose of 1 g per 1 liter of water for 10 days in a row, allowed 100% of rabbits to be completely free from eimeria on the 9th day of experience and improves regenerative processes in the small intestine and liver.
Keywords: rabbit, coccidiosis, eimeriosis, treatment, morphological changes, probiotic, liver, intestines, histology, extensivity, intensivity.
References:
1. Bakrieva R. et al. Effektivnost sochetannogo primeneniya khimiopreparatov s probiotikami pri eymerioze tsyplyat [Efficacy of combined use of chemotherapy drugs with probiotics at eimeriosis in chicken // Veterinariya i kormlenibie. - 2020 (4). - pp.13-15.
2. Zinchenko E.V., Panin A.N. Immunobiotiki v veterinarnoy praktike: o mekhanizme deystviya probiotikov i immunoprobioticheskikh preparatov pri ispolzovanii ikh v veterinarii [Immunobiotics in veterinary practice: on the mechanism of action of probiotics and immunoprobiotic drugs when used in veterinary medicine]. - Pushkino, 2000. - p. 163.
3. Krasnokutsky R. et al. Ispolzovanie probiotika mutsinol v pushnom zverovodstve i krolikovodstve [The use of probiotic mucinol in fur farming and rabbit breeding]. - Zootechnia. - 2017 (12). - pp. 13-15.
4. Mayorova A.S. Vliyanie probiotikov s antitoksicheskoy aktivnostyu na produktivnost krolikov [Effect of probiotics with antitoxic activity on the productivity of rabbits]. - 2007: 120 p.
5. Makhieva B. M., Ozdemirova D. M. Preparat eymeterm v sochetanii s probiotikom pri eymerioze tsyplyat-broylerov [Eimeterm in combination with a probiotic for eimeriosis of broiler chickens]. - Veterinariya i kormlenie. -2021 (5). - pp. 50-52.
6. Merkulov G.A. Course of pathohistological technique [Kurs patologogistologicheskoy tekhniki]. - Medgiz, 1956. - 263 p.
7. Nikonorova V.G. Indeksnyy metod, statisticheskie metody i
matematicheskie modeli v parazitologi [Index method, statistical methods and mathematical models in parasitology]. - International Journal of Applied and Fundamental Research. - 2020 (8). - pp. 12-16.
8. Pleshkov V. A. et al. Probiotik Mutsinol Ekstra v ratsionakh molodnyaka ovets [Probiotic Mucinol Extra in the diets of young sheep]. - 2022.
9. Pokhilenko V. D. et al. Probiotiki na osnove sporoobrazuyushchikh bakteriy i ikh bezopasnost [Probiotics based on spore-forming bacteria and their safety]. - Chemical and biological safety. - 2007 (2-3). - pp. 20-41.
10. Samuylenko A. Ya. et al. Ispolzovanie probiotika s khitozanom pri vyrashchivanii telyat [Use of probiotic with chitosan in the cultivation of calves]. - Proceedings of the Ufa Scientific Center of the Russian Academy of Sciences. - 2016 (3-1). - pp. 160-162.
11. Skryabin S. O. Ispolzovanie probiotika oralin 35 G s tselyu profilaktiki eymerioza krolikov [Use of probiotic oralin 35 G for the prevention of rabbit eimeriosis]. - Rabbit breeding and animal husbandry. - 2011 (4). - pp. 27-28.
12-13. Vide supra.
Author affiliation:
Petrova Irina V., Ph.D. in Veterinary Medicine, senior scientific researcher of the Scientific Research Institute of Fur-Bearing Animal Breeding and Rabbit Breeding named after V.A. Afanasyev; 6, Trudovaya st., Rodniki sttl., Ramensky district, Moscow region, 140143; phone: 8-496-4648681; e-mail: niipzk@mail.ru.
Zhilina Kseniya V., veterinarian of the Scientific Research Institute of FurBearing Animal Breeding and Rabbit Breeding named after V.A. Afanasyev; 6, Trudovaya st., Rodniki sttl., Ramensky district, Moscow region, 140143; phone: 8-496-4648681; e-mail: niipzk@mail.ru.
Responsible for correspondence with the editorial board: Semikrasova Alla N., Ph.D. in Biology, scientific consultant of the Scientific Research Institute of FurBearing Animal Breeding and Rabbit Breeding named after V.A. Afanasyev; 6, Trudovaya st., Rodniki sttl., Ramensky district, Moscow region, 140143; phone: 8-496-4648681; e-mail: niipzk-vet@mail.ru.
http://vetkuban.com/en/num4_202309.html