Tetrasolvin efficiency at endometritis in high productive animals

Bakhmut V.N., Troshin A.N.

Summary

Growth of the dairy efficiency accompanied with essential decrease in indices of reproduction, increases of endometrites was observed in the recent decades in cattle breeding. Antimicrobic preparations are used for treatment of endometritis. But their efficiency is often insufficient. Autors made a complex liquid antimicrobic preparation of antibiotics tetracycline and chloramphenicol – tetrasolvin. Standard documentation on production, quality control and application was developed. Physical. chemical and main pharmaco-toxicological properties of tetrasolvin were studied. Pharmacocinetics of a tetrasolvin is characterized by fast adsorption from a place of the injection, detection in blood serum in 30 minutes, achievement of the maximum concentration of antibiotics in 6-9 hours and finding of therapeutic concentration of antibiotics (0,2 and 0,3 ml/kg of weight of a body) in blood serum within 72 hours; residual amounts of active ingredients are found in 120 hours after the last use of a preparation. Use of animals on meat is authorized not earlier than 7-8 days. Preventive and therapeutic efficiency of tetrasolvin at endometritises of cows (87 and 80%) and sows (93 and 90%) was studied.

Key words: tetrasolvin, tetracycline, chloramphenicol, cows, pigs, endometritis, metrit-mastitis-agalaktiya, efficiency, toxicity, pharmacological properties.

References

  1. Degtyareva S.S., Koba I.S. Chuvstvitelnost mikroflory k razlichnym lekarstvennym preparatam [Sensitivity of microflora to various medicines]. – Krasnodar, 2001. – pp. 336 – 338.
  2. Ilinsky E.V., Nazarov M.V., Troshin A.N., Shevkoplyas V.N. Rukovodstvo po akusherstvu, ginekologii i biotehnike razmnozheniya zhivotnykh [Manual on obstetrics, gynecology and reproduction of animals]. Krasnodar, 2002.
  3. Smirnov A.M., Dorozhkin V.I. Nauchno-metodologicheskie aspekty issledovaniya toksicheskikh svoystv farmakologicheskikh lekarstvennykh sredstv dlya zhivotnykh [Scientific and methodological aspects of research of toxic properties of pharmacological medicines for animals]. – 2008.
  4. Troshin N.A., Troshin A.N. Tetrasolvin – effektivny preparat pri lechenii korov bolnykh poslerodovymi endometritami [Tetrasolvin – effective preparation at treatment of cows’ endometritis]. – Krasnodar, 2001. – pp. 124-125.
  5. Shaposhnikov I.T. Terapiya endometita u korov rotatsionnymi preparatami [Therapy of endometritis at cows with rotary preparations]. – Veterinarnaya patologiya, 2011, #3. – pp. 51-54.
  6. Opsomer, G. Metritis and endometritis in high yielding dairy cows / G.Opsomer, A. de Kruif // Vlaams Diergeneeskundig Tijdschrift. 78. – 2009. – P. 83-88.

Author affiliation

Bakhmut Victoria N., graduate student of the department of therapy and pharmacology of the Kuban State Agrarian University; 13, Kalinina st., Krasnodar, 350044; 8 (861) 2216220; e-mail: knivi@list.ru.

Responsible for correspondence with the editorial board: Troshin Andrey N., Ph.D. in Veterinary Medicine, docent of the department of therapy and pharmacology of the Kuban State Agrarian University; 1 à, Mayakovsky st., Timashevsk, 352700; phone: 8 (86130) 40789, e-mail: andrew70@mail.ru.

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