ÓÄÊ 619:616.636.4;59.006
DOI 10.33861/2071-8020-2025-3-17-21
Original Empirical Research
Aliev A.Yu., Fedotov S.V., Latynina E.S., Sadykhov E.F.
Abstract. In large pig farms with intensive rearing methods, antibiotics are widely used, including for growth stimulation. To reduce the use of antibiotics in pig farming, it is necessary to introduce alternative drugs that support the health of a large number of animals and offspring. This group of drugs includes immunomodulatory compounds. The aim of the study was to determine the therapeutic efficacy of a new immunostimulating drug containing probiotic bacteria lysates on replacement pigs. On the 30th day after the introduction of the studied immunostimulant, the pigs showed a significant increase in hematological, biochemical and immunological parameters. In all experimental groups of piglets, an increase in natural resistance was expressed, as indicated by an increase in the phagocytic activity of neutrophils and lysozyme activity of blood serum. The use of the drug promotes the activation of the pigs’ immune system. During the experiment, with the introduction of the studied immunomodulator, immunoglobulin A doubled. A significant increase in the number of IgG, IgM was also noted. The animals that received the drug demonstrated an increase in IgG with a subsequent increase, as well as an increase of more than seventy percent in IgM and IgA.
Keywords: pigs, immunomodulator, lymphocytes, phagocytic activity of the blood.
Author affiliation:
Fedotov Sergey V., D.Sc. in Veterinary Medicine, Professor of the Department of Veterinary Medicine of the Russian State Agrarian University -Moscow Timiryazev Agricultural Academy; 49, Timiryazevskaya str., Moscow, 127434; e-mail: serfv@mail.ru.
Latynina Evgeniya S., Ph.D. in Veterinary Medicine, Associate Professor of the Department of Veterinary Medicine of the Russian State Agrarian University - Moscow Timiryazev Agricultural Academy; 49, Timiryazevskaya str., Moscow, 127434.
Sadykhov Eduard F., postgraduate student of the Department of Veterinary Medicine of the Russian State Agrarian University - Moscow Timiryazev Agricultural Academy; 49, Timiryazevskaya str., Moscow, 127434.
Responsible for correspondence with the editorial board: Aliev Ayub Yu., D.Sc. in Veterinary Medicine, Director the Caspian Zonal Scientific Research Veterinary Institute - branch of the Federal Agrarian Scientific Center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; phone: 8-928-5715784; e-mail: alievayb1@mail.ru.
Authors’ Contribution:
Aliev A.Yu.: conceptualization, data curation, writing - review and editing;
Fedotov S.V.: methodology, data curation, resources, writing - review and editing;
Latynina E.S.: investigation, formal analysis, visualization, writing -original draft preparation;
Sadykhov E.F.: investigation, validation, visualization, writing - original draft preparation.
Conflict of Interest Statement: the authors declare no conflict of interest.
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