ÓÄÊ 619:616.995.132.5:615.036.8
DOI 10.33861/2071-8020-2023-2-53-56
Kaloshkin I. V., Kabardiev S. Sh., Bittirov A. M., Kalabekov M. I., Didanova A. A., Bittirov I. A.
Summary. Authors determined the therapeutic dose and test the new drug Prazimed A for efficacy and biosafety in an experimental model of canine echinococcosis. With a single application of Prazimed A for echinococcosis in dogs at a dose of 10.0 mg/ kg of live weight, the extent- and intensity efficiency on day 5 was 100%, in the next 7 and 10 days of research, no taeniid-type eggs were found in the feces. In dogs of the control group, the infection of Echinococcus granulosus remained at the level of 100% when eggs were found in 1 g of feces in the range of 4.89±0.40-4.96±0.43, P<0.05 ind., which represents a sanitary and hygienic problem. Echinococcosis negatively affects the morphological composition of the blood of dogs. The content of erythrocytes was 3.97x1012/ - 4.10x1012/| in the blood of control dogs infected with echinococcosis. It indicates the development of permanent erythropenia. In dogs, after treatment of echinococcosis with Prazimed A at a dose of 10.0 mg/kg of live weight, once on days 3, 5, 7, 10, the number of erythrocytes increased from 4.30±0.32x1012/| to 6.24±0.43x1012/| (increase by 31.2%). The content of leukocytes in the blood of control dogs infected with echinococcosis varied on average from 23.44±1.53x109/l to 26.14±1.59x1012/l, which indicates the constancy of leukocytosis. In the experiment after the treatment of echinococcosis with Prazimed A at a dose of 10.0 mg/kg of live weight, once in dogs on days 3, 5, 7, 10, the number of leukocytes decreased from 20.76x109/l to 8.96x109/l. The drug Prazimed A at a dose of 10.0 mg/kg of live weight, once on day 7 and 10 removes leukocytosis from the date of appointment. In the blood of control dogs infected with echinococcosis, the hemoglobin content was 92.8±7.0 g/l - 94.8±7.6 g/l, which indicates the development of hypogemaglobinemia. In dogs after treatment of echinococcosis with Prazimed A at a dose of 10.0 mg/kg of live weight, once for 3, 5, 7, 10 days hemoglobin content increased from 97.2 g/l to 136.2 g/l. Prazimed A in this dose for 7 and 10 days from the date of appointment restores hemoglobinopoiesis to normal. The dynamics of eosinophils in normal and pathological conditions of the organism of animals and humans is a test that determines the depth of changes. The average content of eosinophils in the blood of control dogs infected with echinococcosis was 5 763±438 - 5 874±459 ind./ml, which indicates the development of persistent eosinophilia. In the experiment after treatment of echinococcosis with Prazimed A at a dose of 10.0 mg/kg of live weight, once in dogs on days 3, 5, 7, 10, the number of eosinophils decreased from 5 529±421 ind./ml to 919±82 ind./ml (by 6.02 times). In dogs, Prazimed A at a dose of 10.0 mg/kg of live weight, once on day 7 and 10 removes eosinophilia from the date of appointment, which confirms the high effect and biosafety of the new drug.
Keywords: dog, echinococcosis, drug, Prazimed A, dose, morphology, blood, extensive efficiency, intensity efficiency.
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Author affiliation:
Kaloshkin Igor V., post-graduate student of the Department of therapy and pharmacology of the Kuban State Agrarian University named after I.T. Trubilin; 13, Kalinina st., Krasnodar, 350044; phone: 8-918-2513000; e-mail: kaloshkinigor@mail.ru.
Kabardiev Sadrutdin Sh., D.Sc. in Veterinary Medicine, chief scientific researcher of the Laboratory for the study of parasitic diseases of farm animals and birds of the Caspian Zonal Scientific Research Veterinary Institute - branch of the Federal agricultural scientific center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; e-mail: pznivi05@mail.ru.
Kalabekov Mutalif I., D.Sc. in Veterinary Medicine, professor, professor of the Department of Zootechnics and Veterinary and Sanitary Expertise of the Kabardino-Balkaria State Agrarian University named after V.M. Kokov; 1, Lenina st., Nalchik, Republic of Kabardino-Balkaria, 360030.
Didanova Asiyat A., Ph.D. in Biology, docent, docent of the Department of Veterinary Medicine of the Kabardino-Balkaria State Agrarian University named after V.M. Kokov; 1, Lenina st., Nalchik, Republic of Kabardino-Balkaria, 360030.
Bittirov Ismail A., post-graduate student of the Kabardino-Balkaria State Agrarian University named after V.M. Kokov; 1, Lenina st., Nalchik, Republic of Kabardino-Balkaria, 360030; phone: 8-903-6905788; e-mail: bia_1999@mail.ru.
Responsible for correspondence with the editorial board: Bittirov Anatoly M., D.Sc. in Biology, professor, chief scientific researcher of the Laboratory for the study of parasitic diseases of farm animals and birds of the Caspian Zonal Scientific Research Veterinary Institute - branch of the Federal agricultural scientific center of the Republic of Dagestan; 88, Dakhadaeva st., Makhachkala, Republic of Dagestan, 367000; phone: 8-928-7175574; e-mail: bam_58a@mail.ru.
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